3 (Micro) antigens: basis of immunogenicity

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what is an immunogen?

a compound capable of creating an immune response

T or F all immunogens are antigens?

T

T or F All antigens are immunogens

F

T or F, lipids, steroids and nucleic acids are strong immunogens

False, they are weak antigens

What are strong antigens?

polypeptides
polysaccharides
particulate antigens

what is another name for antigenic determinant site?

epitope

what are the requirements for a molecule to be immunogenic(immunogenicity requirements) Hint: there are 5

foreignness
size
chemical composition
route and scheduled of immunization
use of adjuvants

T or F, the more foreign the Ag(phylogenetically), the stronger the immune response

T

T or F, the Antibodies cannot respond to Antigens within the same species

F, they can

What does size of the Ag have to do with the immune response?

The greater the size of the Ag, the larger the immune response

T or F, the more complex the antigen, the harder it is to mount an immune response

F, the more complex, the better the response

What is an adjuvant?

something you mix with an immunogen to increase immunogenicity

How are adjuvant limited in their ability to increase immunogenicity?

they cant make non-immunogenic compounds immunogenic

How do most adjuvants carry out their function(of increasing a compounds immunogenicity)?

they increase macrophage and helper t cell functions

What are thymic(t cell) dependent antigens and thymic(t cell) independent antigens?

They either do or do not stimulate T cells

T or F, most proteins are thymic(t cell) dependent antigens

t

T or F, thymic(t cell) independent antigens will not stimulate T cells but will stimulate b cells?

T

What type of immunoglobulin interacts with thymic(t cell) independent antigens?

IgM

T or F, most T cell independent antigens are Commonly made of repeating units (ex.: carbohydrates, some polymers)

T

What are Haptens?

small compounds that are not immunogenic

T or F, haptens are immunogenic

False

T or F, haptens are antigenic

T, they can become antigenic if conjugated to something immunogenic

T or F, haptens can be made immunogenic with the addition of adjuvants

False

How can haptens become antigenic when they are conjugated to something immunogenic

They acts as epitopes

What is immunological cross reaction?

when an Ab semi reacts with an epitope on an Ag but not all of them. This Ag is not the right one to react fully with the Ab

does cross reactivity result in an immune response?

Yes, it ultimately results in hypersensitivity

T or F, When an Ab binds to an Ag epitope, the rxn is held together by covalent bonds

F, non-covalent

What is antibody affinity?

How strongly a SINGLE Ab binding site binds to a SINGLE epitope of an Ag

What is avidity?

sum of all the affinities across the entire Ab/Ag

T or F, the Ab future response depends on how the Ag is seen for the first time. If the Ag changes conformation, it will no longer be recognized

T

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