| Term | Definition |
|---|
| alpha -1A | prostate smooth muscle |
| alpha-1B | arterioles and veins |
| Alpha-2 | medullary vasomotor center |
| Beta-1 | heart and kidney |
| Beta-2 | airways and arterioles |
| tamsulosin (Flomax) | prototype alpha-1A antagonist - causes increased urinary stream by relaxing prostate smooth muscle; can cause postural HYPOtension |
| doxazosin (Cardura) | prototype alpha-1B antagonist - causes vasodilation; can also increase urinary stream in BPH and may possibly cause postural HYPOtension; may also cause nasal congestion |
| Epi/NE | prototype alpha-1B agonists - cause vasoconstriction; prototype beta-1 agonists - incr'd HR and incr'd contractility |
| clonidine (Catapres) | prototype alpha-2 agonist - causes decr'd sympathetic tone --> decr'd HR and incr'd vasodilation |
| propanolol (Inderal) | prototype beta-1 blocker - causes decr'd HR and decr'd contractility; also causes decr'd renin --> decr'd BP |
| albuteral | prototype beta-2 agonist --> causes bronchodilation |
| clonidine | common alpha-2 agonist --> works on medullary vasomotor center to decrease sympathetic tone |
| methyldopa | common alpha-2 agonist --> works on medullary vasomotor center to decrease sympathetic tone |
| What does clonidine and methyldopa NOT do that alpha BLOCKERS do? | cause postural HYPOtension |
| propanolol | non-selective beta blocker |
| atenolol | cardio-selective (beta-1) beta blocker |
| metoprolol | cardio-selective (beta-1) beta blocker |
| labetalol | combined alpha-1 blocker and non-selective beta blocker --> may be used instead of hydralazine for HTN of pregnancy; may be used in HTN emergency |
| carvedilol | combined alpha-1 blocker and non-selective beta blocker |
| Common uses for selective and non-selective Beta blockers | chronic angina, status post-MI, migraine prophylaxis, hyperthyroid Sxs |
| beta blocker for Open Angle Glaucoma | timolol --> decreases aqueous humor production |
| Do not give non-selective beta blockers to... | asthma pt or COPDer or pt with Raynaud's |
| Do not give beta blockers to a diabetic because... | they may mask the s/sx of hypoglycemia |
| Adverse Effects of Beta Blockers | incr'd triglycerides and decr'd HDL, erectile dysfunction (disappointment), exercise intolerance |
Combine with other sets
Share on Facebook
Share on MySpace