Causing diabetes mellitus (lack of insulin activity)
congenital adrenal hyperplasia (CAH)
A genetic disorder in which one or more enzymes needed for synthesis of cortisol are absent. Because of the low cortisol level, secretion of ACTH by the anterior pituitary is high due to lack of negative feedback inhibition. As a result, the adrenal glands become enlarged. This leads to virilism, or masculinization.
seasonal affective disorder (SAD)
A type of depression that afflicts some people during the winter months, when day length is short. It is thought to be due, in part, to overproduction of melatonin.
nonsteroidal anti-inflammatory drugs (NSAIDs)
Drugs such as ibuprofen (Motrin) that inhibit cycloxygenase (COX), a key enzyme involved in prostaglandin synthesis. These drugs are used to treat a wide variety of inflammatory disorders, from rheumatoid arthritis to tennis elbow. The success of the drug in reducnig fever, pain, and inflammation shows how prostaglandins contribute to these woes.
posttraumatic stress disorder (PTSD)
An anxiety disorder that may develop in an individual who has experience, witnessed, or learned about a physically or physiologically distressing event.