lab stats

Created by xoj3nn3rsox 

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accuracy

measured v. true value

analytical variation: how to know if therapy changed lab? examples?

how to see if therapy changed lab, 3SD between 1st and subsequent msmt=95% confident; hemolysis, lipidemia, ictonic

effect of hemolysis on lab values

decrease Na+, increase K+, trans ALT, folates

intraindividual var cause

hydration, food intake, activity, stress, posture, circadian rhythm

interindividual variation

age, sex, diet, body mass, activity level, genetics

-PV

TN/(TN+FN)

+PV

TP/(TP+FP)

sensitivity

disease pop, TP/(TP+FN)

specificity

healthy pop, TN/(TN+FP)

sources of variation

hemolysis, drugs

barbituate effect on bilirubin

decrease because glucaronic transferase induced

drugs causing liver toxicity effect on bilirubin

increase bilirubin values

opiates effect on amylase

increase amylase values

quinidine effect on serum digoxin

increase because quinidine releases digoxin from heart muscle and decreases renal clearance

establish reference ranges gaussian

2SD+/- mean

establish reference ranges non-gaussian

inner 95% fo population

alkaline phosphatase results in kids

increase

ammonia results in kids

increase

AST results in kids

increase

bilirubin results in kids

increase

CK results in kids

increase

K+ results in kids

increase

GGT results in kids

gammy glutanyl transferase increase

TSH, T4 results in kids

increase

bicarbonate results in kids

decrease

albumin results in kids

decrease

creatinine results in kids

decrease

amylase results in kids

decrease

cholesterol results in kids

decrease

copper results in kids

decrease

glucose results in kids

decrease

haptoglobin results in kids

decrease

igA,E,M osmolality results in kids

decrease

why do lab techs use controls

Controls distinguish between random variation (inevitable) and systemic error (2x SD)

precision expressed as SD an coef of variation

coef of var= (sd/mean), sd= sqrt variance

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