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5 Written Questions

5 Matching Questions

  1. AMOXICILLIN
  2. LEVOFLOXACIN
  3. AMOXICILLIN Nursing implications -
  4. GENTAMICIN use
  5. PIPERACILLIN Use
  1. a Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
    › Staphylococcus epidermidis.
    › Staphylococcus saprophyticus.
    › Streptococcus pyogenes.
    › Streptococcus pneumoniae.
    › Enterococcus faecalis.
    › Bacillus anthracis.
    Gram-negative spectrum notable for activity against. › Escherichia coli.
    › Klebsiella pneumoniae.
    › Enterobacter cloacae.
    › Proteus mirabilis.
    › Pseudomonas aeruginosa.
    › Serratia marcescens.
    › Haemophilus influenzae.
    › Moraxella catarrhalis.
    Additional spectrum includes. › Chlamydophylia pneumoniae.
    › Legionella pneumoniae.
    › Mycoplasma pneumoniae.

    Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract infections, including cystitis, pyelonephritis, and prostatitis.
    › Respiratory tract infections, including acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, and nosocomial pneumonia.
    › Uncomplicated and complicated skin and skin structure infections.
    • Post-exposure treatment of inhalational anthrax

    Side Effect -d/n/v/r; seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, QTc prolongation, arrhythmias, hepatotoxicity, pseudomembranous colitis, abdomininal pain, vaginitis, photosensitivity, hyper/hypeglcemia, phlenbitis @IV site, peripheral neuropathy, arthralgia, tendinitis, tendon rupture, anaphylaxis

    Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
    • Pedi: Children <18 yr [except for inhalational anthrax (post-exposure)].
    • OB: Pregnancy.

    Nursing implications - PO; intermittent infusion

    Trade / Generic Name - Levaquin

    Classification - Fluoroquinolones; anti-infectives

    Dosage: Most infections PO 250-750 mg q 24hrs
    Inhalation Anthrax 500mg daily for 60 days
  2. b Action - Binds to bacterial cell wall, causing cell death; bactericidal action; spectrum is broader than penicillins

    Use- skin & skin structure infections, otitis media, sinusitis, respiratory infections, genitourinary infections, endocarditis prophylaxis, postexposure inhalational anthrax prophylaxis, mgmt of ulcer disease due to Helicobacter pylori

    Side Effect - d/n/v/r, seizures (high Doses), increase liver enzymes, urticaria, blood dyscrasias, anaphylaxis, serum sickness, superinfection

    Contraindictions - Hypersensitivity to penicillins (cross-sensitivity exists to cephalosporins and other beta-lactams). Tablets for oral suspension (DisperMox) contain aspartame

    Nursing implications - PO ; Less GI distress than Ampilicin; s/s anaphylaxis, Monitor bowl function

    Trade/Generic Name - Amoxil, DisperMox, Moxatag, Trimox

    Classification - aminopenicillins; anti-infectives, antiulcer agents

    Dosage: PO 250-500mg q 8hrs
    500-875mg q 12hrs
  3. c PO ; Less GI distress than Ampilicin; s/s anaphylaxis, Monitor bowl function
  4. d Appendicitis and peritonitis, Skin and skin structure infections, Gynecologic infections, Community-acquired and nosocomial pneumonia caused by piperacillin-resistant, beta-lactamase-producing bacteria.
  5. e Treatment of serious gram-negative bacterial infections and infections caused by staphylococci when penicillins or other less toxic drugs are contraindicated.
    • In combination with other agents in the management of serious enterococcal infections.
    • Prevention of infective endocarditis.
    • Topical, Ophth: Treatment of localized infections due to susceptible organisms.

5 Multiple Choice Questions

  1. Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
    › Staphylococcus epidermidis.
    › Staphylococcus saprophyticus.
    › Streptococcus pyogenes.
    › Streptococcus pneumoniae.
    › Enterococcus faecalis.
    › Bacillus anthracis (anthrax).
    • Gram-negative spectrum notable for activity against. › Escherichia coli.
    › Klebsiella pneumoniae.
    › Enterobacter cloacae.
    › Salmonella typhi.
    › Shigella spp.
    › Proteus mirabilis.
    › Proteus vulgaris.
    › Providencia stuartii.
    › Providencia rettgeri.
    › Morganella morganii.
    › Pseudomonas aeruginosa.
    › Serratia marcescens.
    › Haemophilus influenzae.
    › Neisseria gonorrhoeae.
    › Moraxella catarrhalis.
    › Campylobacter jejuni.

    Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract and gynecologic infections, including cystitis, gonorrhea, and prostatitis.
    › Respiratory tract infections including acute sinusitis, acute exacerbations of chronic bronchitis, and pneumonia.
    › Skin and skin structure infections .
    › Bone and joint infections .
    › Infectious diarrhea .
    › Complicated intra-abdominal infections (with metronidazole).
    › Typhoid fever.
    • Post-exposure prophylaxis of inhalational anthrax.
    • Cutaneous anthrax.

    Side Effect - Seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, d/n/r , pseudomembranous colitis, abdominal pain, abnormal liver enzymes, vaginitis, photosensitivity, hyperglycemia, hypoglycemia, eosinophilia, phlebitits at IV site, tendinitis, tendon rupture, peripheral neuropathy, anaphylaxis

    Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
    • OB: Do not use unless potential benefit outweighs potential fetal risk.
    • Pedi: Use only for treatment of anthrax and complicated urinary tract infections in children 1-17 years due to possible arthropathy.

    Nursing implications - PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function

    Trade / Generic Name - Cipro, Cipro XR, Proquin XR

    Classification - Fluoroquinolones; anti-infectives

    Dosage: PO 500-750 mg q 12hrs
    IV 400 mg q 12 hrs
  2. PO; intermittent infusion
  3. - seizures, Nephritis, urticaria, allergic reaction ; Pain @ IM Site
  4. Nursing implications - PO(Administer at the start of a meal to enhance absorption and to decrease GI side effects. Do not administer with high fat meals; clavulanate absorption is decreased.)
  5. Binds to bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria. Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens

5 True/False Questions

  1. CIPROFLOXACIN side effects are-d/n/v/r; seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, QTc prolongation, arrhythmias, hepatotoxicity, pseudomembranous colitis, abdomininal pain, vaginitis, photosensitivity, hyper/hypeglcemia, phlenbitis @IV site, peripheral neuropathy, arthralgia, tendinitis, tendon rupture, anaphylaxis

          

  2. AUGMENTIN (Amoxicillin/Clavulanate) Contraindictions -Binds to bacterial cell wall, causing cell death; spectrum of amoxicillin is broader than penicillin. Clavulanate resists action of beta-lactamase, an enzyme produced by bacteria that is capable of inactivating some penicillins; Bactericidal action against susceptible bacteria

          

  3. AMPICILLIN Contraindictions -hypersensitivity to penicillins

          

  4. CEFUROXIME side effects are- d/n/v/r; seizures(high doses), pseudomembranous colitis, cramps, Stevens-Johnson Syndrome, Pruritis, urticaria, leucopenia, neutropenia, thrombocytopenia, pain at IM site, phlebitis at IV site, anaphylaxis serum sickness, superinfection

          

  5. CEFTRIAXONE side effects aresezures (High doses), pseudomembranous colitis, d/, cholelithaiasis, gallbladder sludging, rashes, urticaria, bleeding, eosinophilia, hemolytic anemia, leucopenia, thrombocytosis, pain @ IM site, phlebitis at IV site, anaphylaxis, superinfection

          

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