← Antobiotic Drugs Test
5 Written Questions
5 Matching Questions
- AUGMENTIN (Amoxicillin/Clavulanate)
- AUGMENTIN (Amoxicillin/Clavulanate) Action-
- OXACILLIN Nursing Implications -
- a Binds to bacterial cell wall, causing cell death; spectrum of amoxicillin is broader than penicillin. Clavulanate resists action of beta-lactamase, an enzyme produced by bacteria that is capable of inactivating some penicillins; Bactericidal action against susceptible bacteria
- b IM, IV, & intermittent Infusion; Observe for signs & symptoms of anaphylaxis
- c Action- Binds to bacterial cell wall, causing cell death; spectrum of amoxicillin is broader than penicillin. Clavulanate resists action of beta-lactamase, an enzyme produced by bacteria that is capable of inactivating some penicillins; Bactericidal action against susceptible bacteria(Active against Streptococci. Pneumococci. › Enterococci. Haemophilus influenzae. Escherichia coli. Proteus mirabilis Neisseria meningitidis. N. Gonorrhoeae. Staphylococcus aureus Klebsiella pneumoniae. Shigella Salmonella. Moraxella catarrhalis
Use- Skin and skin structure infection Otitis media, Sinusitis Respiratory tract infections, Genitourinary tract infections.
Side Effect - d/v/n/r urticaria, seizures(high doses) pseudomembranous colitis, hepatic dysfunction, vaginal candidiasis, blood dycrasias, allergic reactions including anaphylaxis & serum sickness, superinfection
Contraindictions - Hypersensitivity to penicillins or clavulanate, Suspension and chewable tablets contain aspartame and should be avoided in phenylketonurics; History of amoxicillin/clavulanate-associated cholestatic jaundice.
Nursing implications - PO(Administer at the start of a meal to enhance absorption and to decrease GI side effects. Do not administer with high fat meals; clavulanate absorption is decreased.)
Trade/ Genetric Name - Amoclan, Augmentin, Augmentin ES, Augmentin XR
Classification - aminopenicillins beta lactamase inhibitors; anti-infectives
Dosage: PO 250mg q 8hrs
500mg q 12hrs
- d Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
› Staphylococcus epidermidis.
› Staphylococcus saprophyticus.
› Streptococcus pyogenes.
› Streptococcus pneumoniae.
› Enterococcus faecalis.
› Bacillus anthracis.
Gram-negative spectrum notable for activity against. › Escherichia coli.
› Klebsiella pneumoniae.
› Enterobacter cloacae.
› Proteus mirabilis.
› Pseudomonas aeruginosa.
› Serratia marcescens.
› Haemophilus influenzae.
› Moraxella catarrhalis.
Additional spectrum includes. › Chlamydophylia pneumoniae.
› Legionella pneumoniae.
› Mycoplasma pneumoniae.
Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract infections, including cystitis, pyelonephritis, and prostatitis.
› Respiratory tract infections, including acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, and nosocomial pneumonia.
› Uncomplicated and complicated skin and skin structure infections.
• Post-exposure treatment of inhalational anthrax
Side Effect -d/n/v/r; seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, QTc prolongation, arrhythmias, hepatotoxicity, pseudomembranous colitis, abdomininal pain, vaginitis, photosensitivity, hyper/hypeglcemia, phlenbitis @IV site, peripheral neuropathy, arthralgia, tendinitis, tendon rupture, anaphylaxis
Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
• Pedi: Children <18 yr [except for inhalational anthrax (post-exposure)].
• OB: Pregnancy.
Nursing implications - PO; intermittent infusion
Trade / Generic Name - Levaquin
Classification - Fluoroquinolones; anti-infectives
Dosage: Most infections PO 250-750 mg q 24hrs
Inhalation Anthrax 500mg daily for 60 days
- e Action - Binds to bacterial cell wall membrane, causing cell death. Spectrum is extended compared with other penicillins; Death of susceptible bacteria( active against piperacillin-resistant, beta-lactamase-producing)
Use - Appendicitis and peritonitis, Skin and skin structure infections, Gynecologic infections, Community-acquired and nosocomial pneumonia caused by piperacillin-resistant, beta-lactamase-producing bacteria.
Side Effect - d/n/v/r/ constipation, drug induced hepatitis, confusion dizziness, headache, insomnia, lethargy, interstitial nephritis, bleeding ,leucopenia, neutropenia, thrombocytopenia, pain, phlebitis at IV site; hypersensitivity reactions, serum sickness, fever(increase in cystic fibrosis patients), superinfection
Contraindictions - Hypersensitivity to penicillins, beta-lactams, cephalosporins, or tazobactam (cross-sensitivity may occur
Nursing implications - intermittent infusion ; s/s of anaphylaxis
Trade / Generic Name - Zosyn
Classification - extended spectrum penicillins; anti infectives
Dosage: Most infections 3.375gm q 6hrs
4.5 gm q 6hrs
5 Multiple Choice Questions
- IM / IV use for moderately severe to severe infections; change to PO asap; s/s anaphylaxis & monitor bowl functions
- Previous hypersensitivity to penicillin
- Nursing implications- IV; IM; Intermittent infusion
- Action - Binds to bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria; Active against many gram-positive cocci including
- Inhibits protein synthesis in bacteria at level of 30S ribosome; Bactericidal action; Notable for activity against. ›
5 True/False Questions
CEFAZOLIN use → Treatment of the following infections due to susceptible organisms, Skin and skin structure infections (including burn wounds). Pneumonia, Urinary tract infections, Biliary tract infections, Genital infections, Bone and joint infections, Septicemia, Bacterial endocarditis prophylaxis for dental and upper respiratory procedures; Perioperative prophylaxis
GENTAMICIN Nursing implications - → Nursing implications - Keep patient well Hydrated, IM; Intermittent infusion; topical
Evaluate 8th cranial nerve function, I/O, assess for superinfection
OXACILLIN Contraindictions - → Hypersensitivity to penicillins (cross-sensitivity exists to cephalosporins and other beta-lactams). Tablets for oral suspension (DisperMox) contain aspartame
AMOXICILLIN side effects are → Seizures(high doses) pseudomembranous colitis, d/n/v/r, urticaria, blood dysrasias, anaphylaxis serum sickness, superinfection
CIPROFLOXACIN Contraindictions - → Hypersensitivity (cross-sensitivity within class may exist).
• OB: Do not use unless potential benefit outweighs potential fetal risk.
• Pedi: Use only for treatment of anthrax and complicated urinary tract infections in children 1-17 years due to possible arthropathy