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5 Written Questions

5 Matching Questions

  1. LEVOFLOXACIN use
  2. AMPICILLIN side effects are
  3. CIPROFLOXACIN
  4. CEFUROXIME
  5. AMPICILLIN Contraindictions -
  1. a Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
    › Staphylococcus epidermidis.
    › Staphylococcus saprophyticus.
    › Streptococcus pyogenes.
    › Streptococcus pneumoniae.
    › Enterococcus faecalis.
    › Bacillus anthracis (anthrax).
    • Gram-negative spectrum notable for activity against. › Escherichia coli.
    › Klebsiella pneumoniae.
    › Enterobacter cloacae.
    › Salmonella typhi.
    › Shigella spp.
    › Proteus mirabilis.
    › Proteus vulgaris.
    › Providencia stuartii.
    › Providencia rettgeri.
    › Morganella morganii.
    › Pseudomonas aeruginosa.
    › Serratia marcescens.
    › Haemophilus influenzae.
    › Neisseria gonorrhoeae.
    › Moraxella catarrhalis.
    › Campylobacter jejuni.

    Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract and gynecologic infections, including cystitis, gonorrhea, and prostatitis.
    › Respiratory tract infections including acute sinusitis, acute exacerbations of chronic bronchitis, and pneumonia.
    › Skin and skin structure infections .
    › Bone and joint infections .
    › Infectious diarrhea .
    › Complicated intra-abdominal infections (with metronidazole).
    › Typhoid fever.
    • Post-exposure prophylaxis of inhalational anthrax.
    • Cutaneous anthrax.

    Side Effect - Seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, d/n/r , pseudomembranous colitis, abdominal pain, abnormal liver enzymes, vaginitis, photosensitivity, hyperglycemia, hypoglycemia, eosinophilia, phlebitits at IV site, tendinitis, tendon rupture, peripheral neuropathy, anaphylaxis

    Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
    • OB: Do not use unless potential benefit outweighs potential fetal risk.
    • Pedi: Use only for treatment of anthrax and complicated urinary tract infections in children 1-17 years due to possible arthropathy.

    Nursing implications - PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function

    Trade / Generic Name - Cipro, Cipro XR, Proquin XR

    Classification - Fluoroquinolones; anti-infectives

    Dosage: PO 500-750 mg q 12hrs
    IV 400 mg q 12 hrs
  2. b Action - Binds to bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria. Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens including. Haemophilus influenzae (including B -lactamase-producing strains) Haemophilus parainfluenzae
    › Escherichia coli.
    › Klebsiella pneumoniae.
    › Neisseria .
    › Proteus.
    › Moraxella catarrhalis.
    › Borrelia burgdorferi.

    Use - Treatment of. Respiratory tract infections, Skin and skin structure infections, Bone and joint infections (IV), Urinary tract infections, Gynecological infections, Septicemia (IV), Otitis media (PO), Meningitis (IV), Lyme disease (PO); Perioperative prophylaxis (IV).

    Side Effect - d/n/v/r; urticaria, diaper dermatitis, seizures (high doses) pseudomembranous colitis, bleeding eosinophilia, hemolytic anemia, leucopenia, Pain @ IM site, phlebitis @ IV site, allergic reactions including anaphylaxis, superinfection

    Contraindictions - Hypersensitivity to cephalosporins. Serious hypersensitivity to penicillins

    Nursing implications - PO, admin with food; IM/IV, Direct IV, Intermittent infusion

    Trade / Generic Name - Ceftin, zinacef

    Classification - 2nd generation cephalosporins; anti- infectives

    Dosage: PO 250mg q 12hrs- Pharyngitis/tonsillitis, UTI
    250mg-500mg q12- Bronchitis
    IM 750mg q 8hrs UTI
    1.5 q 6hrs- Life threatening infections
  3. c hypersensitivity to penicillins
  4. d PO, IV: Treatment of the following bacterial infections. › Urinary tract infections, including cystitis, pyelonephritis, and prostatitis.
    › Respiratory tract infections, including acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, and nosocomial pneumonia.
    › Uncomplicated and complicated skin and skin structure infections.
    • Post-exposure treatment of inhalational anthrax
  5. e Seizures(high doses) pseudomembranous colitis, d/n/v/r, urticaria, blood dysrasias, anaphylaxis serum sickness, superinfection

5 Multiple Choice Questions

  1. Contraindictions - Hypersensitivity to cephalosporins, Serious hypersensitivity to penicillins
  2. ataxia, vertigo, ototoxicity(vestibulare & cochlear) nephrotoxiticy, muscle paralysis(high parenteral doses); hybersensitivyt reactions
  3. skin & skin structure infections, otitis media, sinusitis, respiratory infections, genitourinary infections, endocarditis prophylaxis, postexposure inhalational anthrax prophylaxis, mgmt of ulcer disease due to Helicobacter pylori
  4. Hypersensitivity to penicillins or clavulanate, Suspension and chewable tablets contain aspartame and should be avoided in phenylketonurics; History of amoxicillin/clavulanate-associated cholestatic jaundice.
  5. Action - Inhibits protein synthesis in bacteria at level of 30S ribosome; Bactericidal action; Notable for activity against. › Pseudomonas aeruginosa.
    › Klebsiella pneumoniae.
    › Escherichia coli.
    › Proteus.
    › Serratia.
    › Acinetobacter.
    › Staphylococcus aureus.
    In treatment of enterococcal infections, synergy with a penicillin is required.

    Use- Treatment of serious gram-negative bacterial infections and infections caused by staphylococci when penicillins or other less toxic drugs are contraindicated.
    • In combination with other agents in the management of serious enterococcal infections.
    • Prevention of infective endocarditis.
    • Topical, Ophth: Treatment of localized infections due to susceptible organisms.

    Side Effect - ataxia, vertigo, ototoxicity(vestibulare & cochlear) nephrotoxiticy, muscle paralysis(high parenteral doses); hybersensitivyt reactions

    Contraindictions - Hypersensitivity to gentamicin or other aminoglycosides.
    • Most parenteral products contain bisulfites and should be avoided in patients with known intolerance.
    • Pedi: Products containing benzyl alcohol should be avoided in neonates.

    Nursing implications - Keep patient well Hydrated, IM; Intermittent infusion; topical
    Evaluate 8th cranial nerve function, I/O, assess for superinfection

    Trade / Generic Name - Garamycin, G-Mycin, Jenamicin

    Classification - Aminoglycosides; anti-infectives

    Dosage: IM/IV 1-2mg/kg q 8hrs up to 6mg/kg a day in 3 divided doses

5 True/False Questions

  1. GENTAMICIN Contraindictions -Hypersensitivity to gentamicin or other aminoglycosides.
    • Most parenteral products contain bisulfites and should be avoided in patients with known intolerance.
    • Pedi: Products containing benzyl alcohol should be avoided in neonates.

          

  2. CIPROFLOXACIN Nursing implications -PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function

          

  3. CEFUROXIME side effects are- d/n/v/r; seizures(high doses), pseudomembranous colitis, cramps, Stevens-Johnson Syndrome, Pruritis, urticaria, leucopenia, neutropenia, thrombocytopenia, pain at IM site, phlebitis at IV site, anaphylaxis serum sickness, superinfection

          

  4. AMOXICILLINAction - Binds to bacterial cell wall, causing cell death; bactericidal action; spectrum is broader than penicillins

    Use- skin & skin structure infections, otitis media, sinusitis, respiratory infections, genitourinary infections, endocarditis prophylaxis, postexposure inhalational anthrax prophylaxis, mgmt of ulcer disease due to Helicobacter pylori

    Side Effect - d/n/v/r, seizures (high Doses), increase liver enzymes, urticaria, blood dyscrasias, anaphylaxis, serum sickness, superinfection

    Contraindictions - Hypersensitivity to penicillins (cross-sensitivity exists to cephalosporins and other beta-lactams). Tablets for oral suspension (DisperMox) contain aspartame

    Nursing implications - PO ; Less GI distress than Ampilicin; s/s anaphylaxis, Monitor bowl function

    Trade/Generic Name - Amoxil, DisperMox, Moxatag, Trimox

    Classification - aminopenicillins; anti-infectives, antiulcer agents

    Dosage: PO 250-500mg q 8hrs
    500-875mg q 12hrs

          

  5. PIPERACILLIN side effects are- d/n/v/r/ constipation, drug induced hepatitis, confusion dizziness, headache, insomnia, lethargy, interstitial nephritis, bleeding ,leucopenia, neutropenia, thrombocytopenia, pain, phlebitis at IV site; hypersensitivity reactions, serum sickness, fever(increase in cystic fibrosis patients), superinfection

          

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