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5 Written questions

5 Matching questions

  1. AUGMENTIN (Amoxicillin/Clavulanate) Use
  2. CEFUROXIME Contraindictions -
  3. AUGMENTIN (Amoxicillin/Clavulanate) side effects are
  4. PIPERACILLIN Use
  5. PENICILLIN G or V Action -
  1. a Appendicitis and peritonitis, Skin and skin structure infections, Gynecologic infections, Community-acquired and nosocomial pneumonia caused by piperacillin-resistant, beta-lactamase-producing bacteria.
  2. b Hypersensitivity to cephalosporins. Serious hypersensitivity to penicillins
  3. c - d/v/n/r urticaria, seizures(high doses) pseudomembranous colitis, hepatic dysfunction, vaginal candidiasis, blood dycrasias, allergic reactions including anaphylaxis & serum sickness, superinfection
  4. d Skin and skin structure infection Otitis media, Sinusitis Respiratory tract infections, Genitourinary tract infections.
  5. e bind to bacterial cell wall, resulting in cell death; gram positive & negative

5 Multiple choice questions

  1. Action - Binds to the bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria; Similar to that of second-generation cephalosporins, but activity against staphylococci is less, while activity against gram-negative pathogens is greater, even for organisms resistant to first- and second-generation agents. Notable is increased action against. › Acinetobacter.
    › Enterobacter.
    › Haemophilus influenzae (including -lactamase-producing strains).
    › Haemophilus parainfluenzae.
    › Escherichia coli.
    › Klebsiella pneumoniae.
    › Morganella morganii.
    › Neisseria.
    › Proteus.
    › Providencia.
    › Serratia.
    › Moraxella catarrhalis.
    Has some activity against anaerobes, includingBacteroides fragilis .

    Use - Treatment of. › Skin and skin structure infections.
    › Bone and joint infections.
    › Complicated and uncomplicated urinary tract infections.
    › Uncomplicated gynecological infections including gonorrhea.
    › Lower respiratory tract infections.
    › Intra-abdominal infections.
    › Septicemia.
    › Meningitis.
    › Otitis media.
    Perioperative prophylaxis

    Side Effect - sezures (High doses), pseudomembranous colitis, d/, cholelithaiasis, gallbladder sludging, rashes, urticaria, bleeding, eosinophilia, hemolytic anemia, leucopenia, thrombocytosis, pain @ IM site, phlebitis at IV site, anaphylaxis, superinfection

    Contraindictions - Hypersensitivity to cephalosporins.
    • Serious hypersensitivity to penicillins.
    • Pedi: Neonates 28 days (use in hyperbilirubinemic neonates may lead to kernicterus).
    • Pedi: Neonates 28 days requiring calcium-containing IV solutions ( risk of precipitation formation).

    Nursing implications- IV; IM; Intermittent infusion

    Trade / Generic Name - Rocephin

    Classification - 3rd Generation cephalosporins; anti-infectives

    Dosage: IM/IV 1-2gm q 12-24hr most infections
    IM 250mg-Gonorehea
    2gm q 12hrs
  2. PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function
  3. Action - Binds to bacterial cell wall, causing cell death; bactericidal action; spectrum is broader than penicillins

    Use- skin & skin structure infections, otitis media, sinusitis, respiratory infections, genitourinary infections, endocarditis prophylaxis, postexposure inhalational anthrax prophylaxis, mgmt of ulcer disease due to Helicobacter pylori

    Side Effect - d/n/v/r, seizures (high Doses), increase liver enzymes, urticaria, blood dyscrasias, anaphylaxis, serum sickness, superinfection

    Contraindictions - Hypersensitivity to penicillins (cross-sensitivity exists to cephalosporins and other beta-lactams). Tablets for oral suspension (DisperMox) contain aspartame

    Nursing implications - PO ; Less GI distress than Ampilicin; s/s anaphylaxis, Monitor bowl function

    Trade/Generic Name - Amoxil, DisperMox, Moxatag, Trimox

    Classification - aminopenicillins; anti-infectives, antiulcer agents

    Dosage: PO 250-500mg q 8hrs
    500-875mg q 12hrs
  4. Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens
  5. Action - Binds to bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria; Active against many gram-positive cocci including. (Streptococcus pneumonia, Group A beta-hemolytic streptococci. , Penicillinase-producing staphylococci) Active against some gram-negative rods including(Proteus mirabilis & Escherichia coli)

    Use - Treatment of the following infections due to susceptible organisms, Skin and skin structure infections (including burn wounds). Pneumonia, Urinary tract infections, Biliary tract infections, Genital infections, Bone and joint infections, Septicemia, Bacterial endocarditis prophylaxis for dental and upper respiratory procedures; Perioperative prophylaxis

    Side Effect - d/n/v/r; seizures(high doses), pseudomembranous colitis, cramps, Stevens-Johnson Syndrome, Pruritis, urticaria, leucopenia, neutropenia, thrombocytopenia, pain at IM site, phlebitis at IV site, anaphylaxis serum sickness, superinfection

    Contraindictions - Hypersensitivity to cephalosporins, Serious hypersensitivity to penicillins

    Nursing implications - IM / IV; observe for s/s of anaphylaxis & monitor bowel function

    Trade / Generic Name - Ancef

    Classification - First Generation cephalosporins; anti- infectives

    Dosage IM/IV 500mg - 2gm q 6-8 hrs max 12gm/day
    Mild infection with gram positive cocci 250-500mg q
    8hrs
    Pneumonia 500mg q 12hrs

5 True/False questions

  1. LEVOFLOXACIN contraindictionsHypersensitivity (cross-sensitivity within class may exist).
    • Pedi: Children <18 yr [except for inhalation anthrax (post-exposure)].
    • OB: Pregnancy.

          

  2. LEVOFLOXACINAction - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
    › Staphylococcus epidermidis.
    › Staphylococcus saprophyticus.
    › Streptococcus pyogenes.
    › Streptococcus pneumoniae.
    › Enterococcus faecalis.
    › Bacillus anthracis.
    Gram-negative spectrum notable for activity against. › Escherichia coli.
    › Klebsiella pneumoniae.
    › Enterobacter cloacae.
    › Proteus mirabilis.
    › Pseudomonas aeruginosa.
    › Serratia marcescens.
    › Haemophilus influenzae.
    › Moraxella catarrhalis.
    Additional spectrum includes. › Chlamydophylia pneumoniae.
    › Legionella pneumoniae.
    › Mycoplasma pneumoniae.

    Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract infections, including cystitis, pyelonephritis, and prostatitis.
    › Respiratory tract infections, including acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, and nosocomial pneumonia.
    › Uncomplicated and complicated skin and skin structure infections.
    • Post-exposure treatment of inhalational anthrax

    Side Effect -d/n/v/r; seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, QTc prolongation, arrhythmias, hepatotoxicity, pseudomembranous colitis, abdomininal pain, vaginitis, photosensitivity, hyper/hypeglcemia, phlenbitis @IV site, peripheral neuropathy, arthralgia, tendinitis, tendon rupture, anaphylaxis

    Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
    • Pedi: Children <18 yr [except for inhalational anthrax (post-exposure)].
    • OB: Pregnancy.

    Nursing implications - PO; intermittent infusion

    Trade / Generic Name - Levaquin

    Classification - Fluoroquinolones; anti-infectives

    Dosage: Most infections PO 250-750 mg q 24hrs
    Inhalation Anthrax 500mg daily for 60 days

          

  3. PIPERACILLIN Nursing implications -IM, IV, & intermittent Infusion; Observe for signs & symptoms of anaphylaxis

          

  4. CEFTRIAXONE Action -Action - Binds to the bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria; Similar to that of second-generation cephalosporins, but activity against staphylococci is less, while activity against gram-negative pathogens is greater, even for organisms resistant to first- and second-generation agents. Notable is increased action against.

          

  5. OxacillinAction - Bind to bacterial cell wall, resulting in cell death; Broad spectrum

    Use - skin & skin structure infections, soft-tissue infections, otitis media, sinusitis, respiratory infections, genitourinary infections, meningitis, septicemia. Endocarditis prophylaxi

    Side Effect - Seizures(high doses) pseudomembranous colitis, d/n/v/r, urticaria, blood dysrasias, anaphylaxis serum sickness, superinfection

    Contraindictions - hypersensitivity to penicillins

    Nursing implications - IM / IV use for moderately severe to severe infections; change to PO asap; s/s anaphylaxis & monitor bowl functions

    Trade/Generic Name - Marcillin, Omnipen, Penbritin, Principen, Polycillin, Totacillin

    Classification - Aminopenicillins; anti-infectives

    Dosage: PO 250-500mg q 6hrs
    IM/IV 500mg to 3gm q 6hrs

          

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