Episomal, high transduction efficiency, infects both replicating and non-replicating cells, elicits and immune response, insert capacity 8-36 kb.
Integrates genome into specific region on human chromosome 19, low immunogenicity, no associated disease, infects both dividing and non-dividing cells, limited insert capacity 5 kb.
Large insert capacity, broad host range, infects dividing and non-dividing cells, mostly cytolytic vectors.
Liposomes/ naked DNA.
No limit to size of deliverable gene, low immunogenicity, poor levels of gene transfer.
Non-pathologic in humans, stably transduces dividing but non non-dividing cells, inserts genome into host DNA, long-term expression, insert capacity 8 kb, inactivated by human complement.