5 Written Questions
5 Matching Questions
- CEFUROXIME Action -
- CEFAZOLIN Contraindictions -
- AMPICILLIN Action -
- What drug is combined with aminoglycosides
- CIPROFLOXACIN Action -
- a PCN
- b Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including.
- c Binds to bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria. Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens
- d Contraindictions - Hypersensitivity to cephalosporins, Serious hypersensitivity to penicillins
- e Bind to bacterial cell wall, resulting in cell death; Broad spectrum
5 Multiple Choice Questions
- d/n/v/r, seizures (high Doses), increase liver enzymes, urticaria, blood dyscrasias, anaphylaxis, serum sickness, superinfection
- Action - Inhibits bacterial DNA synthesis by inhibiting DNA gyrase enzyme.; Death of susceptible bacteria; Active against gram-positive pathogens, including. › Staphylococcus aureus.
› Staphylococcus epidermidis.
› Staphylococcus saprophyticus.
› Streptococcus pyogenes.
› Streptococcus pneumoniae.
› Enterococcus faecalis.
› Bacillus anthracis (anthrax).
• Gram-negative spectrum notable for activity against. › Escherichia coli.
› Klebsiella pneumoniae.
› Enterobacter cloacae.
› Salmonella typhi.
› Shigella spp.
› Proteus mirabilis.
› Proteus vulgaris.
› Providencia stuartii.
› Providencia rettgeri.
› Morganella morganii.
› Pseudomonas aeruginosa.
› Serratia marcescens.
› Haemophilus influenzae.
› Neisseria gonorrhoeae.
› Moraxella catarrhalis.
› Campylobacter jejuni.
Use- PO, IV: Treatment of the following bacterial infections. › Urinary tract and gynecologic infections, including cystitis, gonorrhea, and prostatitis.
› Respiratory tract infections including acute sinusitis, acute exacerbations of chronic bronchitis, and pneumonia.
› Skin and skin structure infections .
› Bone and joint infections .
› Infectious diarrhea .
› Complicated intra-abdominal infections (with metronidazole).
› Typhoid fever.
• Post-exposure prophylaxis of inhalational anthrax.
• Cutaneous anthrax.
Side Effect - Seizures, dizziness, drowsiness, headache, insomnia, agitation, confusion, d/n/r , pseudomembranous colitis, abdominal pain, abnormal liver enzymes, vaginitis, photosensitivity, hyperglycemia, hypoglycemia, eosinophilia, phlebitits at IV site, tendinitis, tendon rupture, peripheral neuropathy, anaphylaxis
Contraindictions - Hypersensitivity (cross-sensitivity within class may exist).
• OB: Do not use unless potential benefit outweighs potential fetal risk.
• Pedi: Use only for treatment of anthrax and complicated urinary tract infections in children 1-17 years due to possible arthropathy.
Nursing implications - PO on empty stomach ; intermittent infusion; observe for s/s of anayphylaxis, monitor bowel function
Trade / Generic Name - Cipro, Cipro XR, Proquin XR
Classification - Fluoroquinolones; anti-infectives
Dosage: PO 500-750 mg q 12hrs
IV 400 mg q 12 hrs
- Action - Binds to the bacterial cell wall membrane, causing cell death; Bactericidal action against susceptible bacteria; Similar to that of second-generation cephalosporins, but activity against staphylococci is less, while activity against gram-negative pathogens is greater, even for organisms resistant to first- and second-generation agents. Notable is increased action against.
- 7-10 days
- - Administer IV / IM = Penicillin G; PO = Penicillin V ; Observe for s/s anaphalxis
5 True/False Questions
Infection → the time between exposure to a pathogen and the onset of symptoms of the disease
When do we test for a trough → test right before you give the next dosage
AMOXICILLIN Contraindictions - → Hypersensitivity to penicillins (cross-sensitivity exists to cephalosporins and other beta-lactams). Tablets for oral suspension (DisperMox) contain aspartame
What are some indication of an infections → temperature, inflammation, increased WBC, exudate
Sensitivity → Action - Inhibits protein synthesis in bacteria at level of 30S ribosome; Bactericidal action; Notable for activity against. › Pseudomonas aeruginosa.
› Klebsiella pneumoniae.
› Escherichia coli.
› Staphylococcus aureus.
In treatment of enterococcal infections, synergy with a penicillin is required.
Use- Treatment of serious gram-negative bacterial infections and infections caused by staphylococci when penicillins or other less toxic drugs are contraindicated.
• In combination with other agents in the management of serious enterococcal infections.
• Prevention of infective endocarditis.
• Topical, Ophth: Treatment of localized infections due to susceptible organisms.
Side Effect - ataxia, vertigo, ototoxicity(vestibulare & cochlear) nephrotoxiticy, muscle paralysis(high parenteral doses); hybersensitivyt reactions
Contraindictions - Hypersensitivity to gentamicin or other aminoglycosides.
• Most parenteral products contain bisulfites and should be avoided in patients with known intolerance.
• Pedi: Products containing benzyl alcohol should be avoided in neonates.
Nursing implications - Keep patient well Hydrated, IM; Intermittent infusion; topical
Evaluate 8th cranial nerve function, I/O, assess for superinfection
Trade / Generic Name - Garamycin, G-Mycin, Jenamicin
Classification - Aminoglycosides; anti-infectives
Dosage: IM/IV 1-2mg/kg q 8hrs up to 6mg/kg a day in 3 divided doses