Immune Alterations and Cancer

5 Written Questions

1. decreased immunity & blood producing functions, altered GI structure and function, motor and sensory deficits, decreased respiratory function
2. shock that develops as the result of infection carried by the bloodstream, eventually causing dysfunction of multiple organ systems.
3. an act that sets in motion some course of events
   ex:smoking, high fat diet, HTN, etc.
4. Plasma; antibodies to ABO blood antigens. Highest in initial exposure
5. Patient experiencing blood transfusion reaction experiances highest levels of what type of immunoglobulin?

5 Matching Questions

1. Hypersensitivity or allergic reaction
2. Cell Mediated immunity
3. Type B
4. Natural Passive Immunity
5. Histologic

1. a cellular aspects,examination,study of tissue
2. b baby receives antibodies from its mother through the placenta and breast milk
3. c an immune response in which killer T cells attack antigen-bearing cells directly
4. d Anti-A antibodies
5. e an over-reaction against foreign antigens 4 types
   1. rapid hypersensitivity (humoral)
   2. cytotoxic/cytolytic reactions (humoral)
   3. immune-complex reactions (humoral)
   4. delayed hypersensitivity reactions (cellular)

5 Multiple Choice Questions

1. Reactions involve IgE mast cells, chemical mediators
   Labs: increased eosinophils, igE
   Allergy testing--skin test, oral food challenges, avoidance therapy, environmental changes, drug therapies/patient education.....antihistamines (block h1/h2 receptors), sympathomimetic/decongestant drugs, corticosteriods, antipruritic meds (anti-itch), mast cell-stabilizing meds, leukotriene receptor antagonists
   1. Type 1 (Rapid Hypersensitivity) "atopic allergy"
   2. Type 1 (Hypersensitivity reaction)
   3. Type 4 (Hypersensitivity reaction)
   4. Type 3 (Hypersensitivity reaction)
2. Day old baby who is breastfeeding receives what type of Immunoglobulin?
   1. TNM
   2. Primary
   3. IgA
   4. IgM
3. Cytotoxic/Cytolytic Reactions (Humoral)
   Production of autoantibodies--destroy own cells/tissue.
   Antibody: IgA, IgM, complement often involved
   Mediators: complement lysis (cell breakdown), macrophages
   Examples:Transfusion reaction, Goodpasture syndrome, ITP, Grave's disease
   1. Type 4 (Hypersensitivity reaction)
   2. Type 2 (Hypersenstivity reaction)
   3. Type 1 (Hypersensitivity reaction)
   4. Hypersensitivity or allergic reaction
4. production of your own antibodies as a result of vaccination or immunization
   1. Natural Active Immunity
   2. Active Passive Immunity
   3. Artificial Active Immunity
   4. Hypercalcemia
5. oncologic emergency with rapid lysis of malignant cells, as the cells lyse, intracellular contents are released in blood which results in hyperkalemia, hyperphosphaemia, and hyperuricemia which puts the patient at risk for renal failure and cardiac function, early signs include n&v, anorexia, diarrhea, muscle weakness and cramping, later signs tetany, paresthesias, seizures, anuria, and cardiac arrest
   1. Tumor Lysis Syndrome
   2. Primary prevention
   3. Type O
   4. Humoral Immunity

5 True/False Questions

1. Active Passive Immunity → Artificial, serum immune globulins/antibody injections

   True        False

2. Progression → process of moving forward, developing
   (no contact inhibition)

   True        False

3. Secondary pervention → Regular screening, altering damaged genes, Genetic screening. detect and treat.

   True        False

4. Basophils and Eosinophils → release chemicals, tissue response

   True        False

5. Type 1 (Hypersensitivity reaction) → Rapid Hypersensitivity (Humoral)
   Can be local or systemic
   Allergens inhaled, ingested, contacted or injected
   Reaction comes from within.
   Reaction involves IgE, mast cells, chemical mediators.

   True        False