Lecture Section - Erythrocytes - Part I - Six Stages of Erythrocytes

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Six stages of erythrocyte development

1. Rubriblast
2. Prorubricyte
3. Rubricyte
4. Metarubricyte
5. Reticulocyte
6. Mature erythrocyte

Rubriblast

also known as Pronormablast or Proerythroblast

Rubriblast

earliest recongnizable red cell precursor

Rubriblast

originates from a commited stem cell which orginated from a pluripotential stem cell

Rubriblast

each pronormoblast produces 8-16 mature red cells

Rubriblast

large round cell, 12-20 micro in diameter

Rubriblast

high nuclear cytoplasm ratio (N:C)

Rubriblast

large reddish-purple nucleus and small amount of deeply basophilic cytoplasm

Rubriblast

chromatin is very fine and "lacy" in appearance

Rubriblast

has one or more nucleoli

Rubriblast

perinuclear halo - clearing around the nucleus - represents mitochondria

Rubriblast

hemehlobin synthesis may begin at this stage but its presence is generally obsucred because of the large nuber of ribosomes

Rubriblast

upon specific stimulation, divides and matures and gives rise to two prorubricytes

Prorubricyte

also known as basophilic normoblast or basophilic erythroblast

Prorubricyte

smaller than rubriblast, 10-16 micro in diameter

Prorubricyte

N:C is decreased

Prorubricyte

more abundant cytoplasm, usually deeply basophilic

Prorubricyte

hemeglobin synthesis may cause areas of pinkish cytoplasm to appear

Prorubricyte

nuclear chromatin becomes coarser

Prorubricyte

majority of hemeglobin is made in this stage

Rubricyte

also known as polychromatophilic normoblast or polychromatophilic erythroblast

Rubricyte

generally 10-12 micro in diameter

Rubricyte

further decreases in N:C ratio

Rubricyte

cytoplasm shows variable amounts of pink coloration mixed with basophilia; can give cell a grey-blue appearance

Rubricyte

large amounts of hemeglobin synthesized in this stage

Rubricyte

last stage capable of mitosis

Metarubricyte

also known as orthochromatophilic normoblast

Metarubricyte

8-12 micro in diameter

Metarubricyte

chromatin is tightly condensed and is described as pyknotic

Metarubricyte

cytoplasm is predominantly pink or salmon pink-indicates presence of large quantities of hemoglobin

Metarubricyte

also has blue-grayish tinge because of RNA

Metarubricyte

nuclear chromatin that is pyknotic is metabolically inactive/dead

Reticulocyte

also known as polychromatophilic erythrocyte

Reticulocyte

young erythrocyte without a nucleus

Reticulocyte

contains residual RNA and mitochondria in cytoplasm which gives cell a bluish tinge on a Wright stain

Reticulocyte

8-10 micro in diameter

Reticulocyte

part of this phase occurs in the bone marrow, later part takes place in circulating blood

Mature erythrocyte

binding, transport, and release of O2 is passive (don't need energy)

Mature erythrocyte

stains pink to orange due to large amount of hemoglobin

Mature erythrocyte

about 7 micro in diameter

Mature erythrocyte

cell has lost all residual RNA and mitochondria, therefore, is incapable of synthesizing new protein or lipid

Mature erythrocyte

normal life span is about 120 days

Mature erythrocyte

has limited metablosim due to absence of nucleus, mitochondria, and other subcellular organelles

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