| Term | Definition |
|---|
| Benzodiazepem | G.A., Binds GABAaR, +Cl- channel opening, +GABA eff, inhib to firing, sedation |
| Barbituate | G.A., Binds GABAaR, +Cl- channel opening, +GABA eff, inhib to firing, sedation, can act ALONE |
| NeuroSteroid | G.A., Binds GABAaR, +Cl- channel opening, +GABA eff, inhib to firing, sedation |
| Propofol | IV G.A. Binds GABAaR alcohol site, incr inhib eff, +Cl- channel opening |
| Thiopental | IV G.A. Binds GABAaR barbituate site, incr inhib eff, +Cl- channel opening |
| Midazolam | IV G.A. Binds GABAaR BDZ site, incr inhib eff, +Cl- channel opening |
| Ketamine | G.A. Binds NMDA-R PCP site, inhib channel opening |
| Phencyclidine | G.A. Binds NMDA-R PCP site, inhib channel opening |
| Lidocaine | L.A. Block voltage gated Na+ channels on unmyel C-fibers & myel A-delta-fibers |
| Triazolam | Sed/Hyp; NonSelective GABAaR+ BDZ site |
| Zaleplon | Sed/Hyp. Selective GABAaR+ BDZ site, a1 |
| Secobarbital | Sed/Hyp. +GABAaR, barbituate site, |
| Chloral Hydrate | Sed/Hyp. +GABAaR, alcohol site |
| Hydroxyzine | Sed/Hyp. -H1-R in CNS |
| Ramelteon | Sed/Hyp, +MT1/MT2 |
| Diazepam | Anxiolytic, Spasmolytic, NonSelective GABAaR+ BDZ site, a1, a2 |
| Buspirone | Anxiolytic, Antidepressant, 5HT-1A/D-R+, longterm down reg of autoR |
| Oxcarbazepine | Anticonvuls, inhib volt-gated Na+ channels |
| Clonazepam | Anticonvuls, direct +GABAaR, BDZ site |
| Phenobarbital | Anticonvuls, direct +GABAaR, Barbitutate site |
| Tiagabine | Anticonvuls, indirect +GABAaR, block GABA reuptake |
| Vigabatrin | Anticonvuls, indirect +GABAaR, decr metab of GABA |
| Gabapentin | Anticonvuls, inhib volt-gated Ca+2 channels T & P/Q type, a2-delta-1 subunit, inhib influx, decr NT released |
| Ethosuximide | Anticonvuls, inhib thalamic T-type Ca+2 channels, absent seizures |
| Levetiracetam | Anticonvuls, inhib N-type Ca+2 channels, binds SV2A, inhib NT release |
| Desipramine | Antidepressant, selective NE reuptake inhib |
| Paroxitine | Antidepressant, SSRI, selective serotonin reuptake inhib |
| Venlafaxine | Antidepressant, SNRI, nonselective amine reuptake inhib |
| Tranylcypromine | Antidepressant, -MAO |
| Mirtazapine | Antidepressant, -a2 , initial inhib of autoR |
| Bupropion | Antidepressant, DA reuptake inhib, D2-R presynap |
| Trazadone | Antidepressant, -5HT-2/1C post synap, least understood mech |
| Levodopa - L-DOPA | AntiParkinson's, restore DA in DA neurons |
| Caridopa | AntiParkinson's, DOPA AAD inhib, incr conc of L-DOPA in periphery |
| Entacapone | AntiParkinson's, -COMT, incr conc of L-DOPA, in periphery |
| Ropinirole | AntiParkinson's, direct +DA |
| Rasagiline | AntiParkinson's, -MAO-B, incr conc of DA in brain |
| Trihexyphenidyl | AntiParkinson's, -M2 |
| Amantadine | AntiParkinson's, mild NCI of NMDA-R, PCP site, lessen/prevent dyskinesais |
| CoQ10 | AntiParkinson's, antioxidant, mito enhancer/protector, prevent brain cells from neurodegeneration |
| Creatine | AntiParkinson's, mito enhancer/protector |
| Haloperidol | Antipsychotic, typical, strong -D2-R, treat pos symptoms, EPS side effects |
| Clozapine | Antipsychotic, atypical, mild -D2-R, treat pos & neg symptoms, no EPS |
| Thioridazine | Antipsychotic, atypical, strong -D2-R & high antiMusc activity (negates D2 block in striatal), low EPS effects |
| Li+ | Mood Stabilizer, inhib dephosphorylation of IP1 -> Inosine, decr PLC |
| Methylphenidate | CNS stimulant, indirect DA/NE agonist, block reuptake and/or incr release of DA/NE |
| Sibutramine | CNS stimulant; indirect; 5HT reuptake inhib; used more for appetite supression |
| Atomoxetine | CNS stimulant, selective NE reuptake inhib, tx ADHD |
| Modafinil | CNS stimulant, +Hypocretin/Orexin-R, weak blockage of DA reuptake |
| Orlistate | CNS stimulant, -lipase, decr fat absorption, not absorbed, no systemic effect |
| Caffeine | CNS stimulant, inhib P1 + Adenosine1,2-R |
| Morphine | Opioid agent, +Mu-R, used mostly for analgesic effect |
| Tramadol | Opioid agent, +Mu-R & SSRI, |
| Tapentadol | Opioid agent, +Mu-R & NE reuptake inhibitor |
| Buprenorphine | Opioid agent, partial +Mu-R, tx/prevent drug abuse |
| Butorphanol | Opioid agent, +Kappa-R & weak -Mu-R |
| Loperamide | Opioid agent, gut +Mu-R, antidiarrheal |
| Codeine | Opioid agent, suppress cough reflex, not true opioid effect |
| Naloxone | Opoid antagonist, pure, treat opioid overdose, treat/prevent drug addition |
| Alvimopan | Opoid antagonist, selective -Mu, treat opioid induced constipation |
| Capsaicin | Opioid-related, analgesia, releases Substance P to desenstize nerve terminal receptors, substance P may be depleted |
| Sumatriptan | Migraine tx; selective +5HT-1B/1D; pre + post synap, inhib migraine generation + decr depol of trigeminal nerve and VAP release |
| Ergotamine | Migraine tx; nonselective +5HT-1 |
| Botulinum Toxin | Migraine tx; block activation of cholinergic neurons |
| Valproate | Migraine tx, AntiConvulsant; prophylaxis; stop initiation of migraine generator by slowing CNS excitability |
| Dantrolene | Spasmolytics; binds RYR-1 of SR; prevent Ca+2 release, prevent EC coupling of muscle fibers |
| Baclofen | Spasmolytics; +GABA-B, inhib neuron depol, inhib release of NT in spinal cord |
| Tizanidine | Spasmolytics; +a2 adrenergic on dorsal horn efferent nerves |
| Chlorphenesin | Spasmolytics; GABA-A+; treat acute local muscle spasms |
| Chlorzoxazone | Spasmolytics; activates K+ channel currents to hyperpol neurons; treat acute local muscle spasms |
| Cyclobenzapine | Spasmolytics; activates neurons in locus coeruleus, incr release NE in ventral horn, +a2 to inhib firing of motorneurons; treat acute local muscle spasms |
| Orphenadrine | Spasmolytics, neuroprotective; potent -H1; uncompetitive -NMDA-R; treat acute local muscle spasms |
| Riluzole | Spasmolytics, Neuropprotective; -N-type Ca+2 channels to inhib Glu release; inhib AMPA+NMDA glu channels; protects against excitotoxicity, prolongs ALS pt life |
| Memantine | Spasmolytics, Neuropprotective; weak -PCP on NMDA, noncompetitive, block excessive opening of Ca+2 channel; Tx: ALZ |
| Donepizil | Spasmolytics; reversible inhib CNS AchE; mild memory enhancement, doesn't slow progression of dz; Tx: ALZ |
| Tetrabenazine | Spasmolytics; depletes stores of all monoamine NT; Tx: Huntington's dz |
Combine with other sets
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