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Babbini, SEM 3, ROSSU

When are bactericidal drugs the first line agents used?

In seriously ill or immunocompromised patients

What is MIC?

Minimum inhibitory concentration, this is the lowest concentration of antibiotic that inhibits growth of tested bacteria

What is MBC?

Minimum Bactericidal Concentration, this is the lowest concentration of an antibiotic that kills the tested bacteria

What does Beta-Lactam inhibit?

Transpeptidase

What does Vancomycin inhibit?

Transglycosylase

What does Fosfomycin inhibit?

Enolpyruvate Transferase

What do the Aminoglycosides inhibit?

The Protein Synthesis by blocking the initiation complex. Translocation is blocked

What do Macrolides block?

Translocation

What does Chloramthenicol block?

Transpeptidation

What do Tetracyclines block?

Aminoacyl-tRNA binding

What does Quinupristin block?

Translocation

What does Dalfopristin do?

It changes the 50s so f. it up

What does Linezolid do?

It blocks the initiation complex

What do Sulfonamides do?

Inhibits Dihydropteroate Synthetase

What does Trimethoprim do?

Inhibits Dihydrogolate reductase

What do Quinolones do?

Inhibit Topoisomerase

What do Metronidazole do?

DNA damage!

What is Prophylactic therapy?

Prevention therapy (antimicrobial)

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