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Physiological Process

Excitement > Plateau > Orgasm > Resolution

Sexual Stimulation

Includes hearing, sight, touch, psyche, and smell
Results in nerve transmission from the brain to the penis, affecting cyclic GMP levels in penis

Cyclic GMP

Increase blood flow in penis - swells and keeps blood from flowing out

Physiology of Erection

Stimulation increases cyclic GMP (enzyme) in penis and relaxation of smooth muscle > Increased blood flow into erectile tissue > Veins carrying blood out are shut off > Blood trapped in erectile tissue

Loss of Erection

Lack of sexual stimulation leads to breakdown of cyclic GMP (enzyme) by PDE5 (breaks down GMP and restores to normal state) > Decreased blood flow into erectile tissue > Blood no longer trapped in erectile tissue

Impotence or Erectile Dysfunction (ED)

Inability to get an erection adequate for satisfactory sexual performance

Impotence ___ with age

Increases

ED Drugs

Ex. Viagra
Allow stimulation to increase cyclic GMP by suppressing enzyme PDE5 that destroys cyclic GMP > Increased blood flow into erectile tissue > Veins carrying blood out are shut off > Blood trapped in erectile tissue

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