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5 Written questions

5 Matching questions

  1. semisynthetic drugs
  2. monobactams
  3. carbapenems
  4. toxic dose
  5. chemotherapeutic agents
  1. a active against aerobic, gram negative rods; narrow spectrum; low toxicity; used for noscomial diseases and bacterial meningitis
  2. b broad spectrum; highly resistant to beta lactamases; last resort for many bacterial infections; primaxin
  3. c concentration of a drug that causes harm to the host
  4. d drugs partly of laboratory origin and partly of microbial origin; improve the natural product; reduce side effects
  5. e used to treat infections, diseases, and other disorders such as cancer

5 Multiple choice questions

  1. used against gram positive; alternative to penicillin; erythromycin blocks protein synthesis by inhibiting chain elongation (ZPAC-azithromycin)
  2. broader spectrum alternative to penicillins; gram positive and gram negative; resistant to many beta lactamases; cefixime
  3. broad spectrum including chlamydias and rickettsais; destroy intestinal microbiota and cause staining of teeth; bind with calcium; put in animal feed
  4. bacteria may evolve the ability to enzymatically inactivate an antibiotic
  5. first modern synthetic antimicrobial agent; Hata and Ehrlich; arshphenamine; used against syphilis

5 True/False questions

  1. synthetic drugdrugs partly of laboratory origin and partly of microbial origin; improve the natural product; reduce side effects

          

  2. target modificationused against gram negative infections of the urinary tract

          

  3. rifampininterferes with nucleic acid synthesis in RNA synthesis; effective against tb, leprosy, meningitis; causes liver damage; used with Isoniazid and Ethambutol

          

  4. active export of antibioticsbacteria may evolve the ability to prevent drug entry into the cytoplasm or to pump the drug out of the cytoplasm

          

  5. sulfonamidesinterfere with the DNA synthesis by competing with PABA in making folic acid; eventually kills the bacterial cell

          

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