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profligate utterly and shamelessly immoral or dissipated; thoroughly dissolute. dissipation a wasting by misuse impassable unable to be surmounted piety reverence for God or devout fulfillment of religious obligations exhorter to urge or persuade (someone) earnestly; advise strongly sagacity acuteness of mental discernment and soundness of judgment. pernicious causing insidious harm or ruin; ruinous; injurious; hurtful