| Term | Definition |
|---|
| alkylating agents | any substance that contains an alkyl radical and is capable of replacing a free hydrogen atom in an organic compound |
| androgens | any steriod hormone that increases male characteristics |
| antimetabolite | a substance that competes with, replaces, or antagonizes a bodily function |
| antineoplastic drugs | an agent used in the treatment of cancer |
| carcinoma | a malignant neoplasm caused by excesssive cellular proliferation; also known as cancer |
| corticosteriod | any of the hormones produced by the adrenal cortex( other than sex hormones) that influence or control key processes of the body |
| estrogens | one of a group of hormonal steriods that promote the development of female sex characteristics |
| neoplasm | an unnatural growth or tumor in the body; a cancer |
| recombinant | a cell or organism that has recieved genes from different parental strains |
| 9 | number of classifications of antieoplastic drugs |
| alkylating agents | alter the chemical composition of proteins (probably the nucleoproteins of the cell |
| first form of antineoplastic therapy | alkylating agent |
| antimetabolites | act by interfering with a specfic cell metabolism compete with replace or antagonize a metabolic or bodily function |
| true | neoplastic cells grow more rapidly than normal cells |
| hormone | antagonize certain tumors of the reproductive tract and accessory sex organs by altering normal hormonal balance |
| corticosteriods | hormones to be valuable in producing remissions of certain maliganices |
| androgens drug (teslac) | analog of testosterone is a hormone dervative used exclusively in the treatment of maliganices |
| antiandrogens (casodex) | used in combination therapy for the treatment of metastatic cancer of the prostrate |
| antiestrogens (faslodex) | used to treat breast cancer in women who have had a recurrence following tamoxifen or aromatase inhibitor theraphy |
| SERMs | selective estrogen receptor modulators---- pocesss a tertiary structure that allows them to bind to estrogen receptor--used to treat diseases caused by estrogen defincienty |
| aromatase inhibitors | used to treat advanced breast cancer in postmenopausal women or may begiven after surgical removal of tumor |
| inhibitors of pituitary hormones (zoladex) | willl reduce the amount of testosterone or estrogen in the bloodstream treats breast prostrate as well as for endometriosis and dysfuctional uterine bleeding |
| antitumor antibiotics | antibiotic agent appears to occur by causing a splitting of the DNA chain or RNA synthesis( treats hodgkin's disease- also squamous cell carcinomas of skin penis vulva head |
| doxorubicin | an antibiotic produced by a strain of Streptomyces---inhibits DNA and RNA synthesis |
| enzyme inhibitors | interfere with tumor enzmes derived from plants --escherichia oil --chinese tree-bark and wood--used in combination with chemothraphy |
| immunomodulating agents in cancer | produced by leukocytes (white blood cells)--enhance body's own defense mechanism--it demonstrated antitumor effects in tissue cultures and animal experiments |
| recombinant DNA | newer form of cancer treatment--cell or organism receives genes from differe nt parental strains |
| molecular and targeted therapies | cellular level in cancer theraphy --agents developed through molecular medicine |
| platinum analogs | plantinum analogs exert their effect by binding elemental platinum to DNA and proteins disrupting their fuction |
| micellaneous cancer treatment agents | have different modes of action -taxotere--hydrea to name a couple |
| supportive agents | aranesp -long acting form of epoetin alfa epigeb oricrut eppietin alfa used for treatment of chemotherapy-induced anemia neupogen G-CSF stimulates formation of white blood cells |
| name the 9 calssifications of antineoplastic drugs | 1alkylating agents 2 antimetabolites 3 hormones 4 antitumor antibiotics 5 enzyme inhibitors 6 immunomodulating agents 7 molecular medicine and gene theraphy 8 platinum analogs 9 miscellaneous drugs |
| hormone | an agent secreted by the endocrine glands into the bloodstream that produces or alters bodily functions |
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