Chapter 11

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Exam 1

1. The principles underlying complication to drug therapy in the elderly include
___________________, ________________, _____________________, and
____________________.

1. The principles underlying complication to drug therapy in the elderly include Altered pharmacokinetics (secondary to organ system degeneration), multiple and severe illnesses, multiple-drug therapy, and poor adherence.

2. Altered absorption of drugs in the elderly may result in
____________________ drug response.

2. Altered absorption of drugs in the elderly may result in delayed drug response.

3. The four major factors that can alter drug distribution in the elderly include
___________________, ______________________, _________________,
and _____________________.

3. The four major factors that can alter drug distribution in the elderly include Increased percent body fat, decreased percent lean body mass, decreased total body water, and reduced concentrations of serum albumin.

4. Because of reduced _______________ levels, protein binding of drugs
decreases, causing level of ____________ to rise.

4. Because of reduced albumin levels, protein binding of drugs decreases, causing level of free drugs to rise.

5. The most important cause of adverse drug reactions in the elderly is
______________________________.

5. The most important cause of adverse drug reactions in the elderly is Drug accumulation secondary to reduced renal excretion.

6. In the elderly, the proper index of renal function is _________________.

6. In the elderly, the proper index of renal function is creatinine clearance.

7. Adverse drug reactions are ________ times more common in the elderly than
in younger adults

7. Adverse drug reactions are 7 times more common in the elderly than in younger adults.

8. Factors underlying the increase in adverse reactions in the geriatric
population include __________________, _________________,
____________, _______________, _____________, and____________________.

8. Factors underlying the increase in adverse reactions in the geriatric population include drug accumulation secondary to reduced renal function, polypharmacy, greater severity of illness, prescence of multiple pathologies, greater use of drugs with low therapeutic index, increased individual variation secondary to altered pharmacokinetics, inadequate supervision of long term therapy, and poor patient adherence.

9. The ________________ identifies drugs with a high likelihood of causing
adverse effects in the elderly

9. The Beers list identifies drugs with a high likelihood of causing adverse effects in the elderly.

10. As many as ________ percent or more of elderly patients fail to take their
medications as prescribed.

10. As many as 40% percent or more of elderly patients fail to take their medications as prescribed.

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