| saccharine | Excessively sweet or sentimental |
| sacrilegious | Irreverent towards those considered sacred or holy |
| salient | Prominent; of pronounced significance |
| sanctimonious | Hypocritically moral or devout |
| satiate | To satisfy a need or desire to the fullest or to excess |
| saturnine | Cold and steady mood; gloomy; slow to react |
| savant | A person of learning; esp. one with extreme knowledge in a certain field |
| seamy | Unpleasant; low in moral standards |
| secular | Not relating to religion; pertaining to the general world |
| sedition | Behavior that promotes open rebellion or disorder against the authority |
| seminal | Influential in an original, creative way; providing a path for further developments |
| sequester | To set apart, seclude; separate |
| seragraphic | Sweet; angelic |
| simian | Apelike; pertaining to apes |
| sinecure | A well-paying job or office that requires little or no work |
| sobriquet | A nickname or alias |
| sojourn | A temporary stay or visit |
| solicitous | Anxious or concerned; full of desire; eager |
| sophomoric | Displaying extreme immaturity and lack of judgement or common sense |
| spartan | Highly self-disciplined |
| specious | Having the effect of truth but actually being false; deceptively attractive or desirable |
| sportive | Playful; frolicsome; pertaining to sports |
| squalid | Filthy and diminished due to neglect or poverty |
| stalwart | Marked by outstanding strength and endurance or body, mind, or soul |
| stasis | A state of equilibrium or inactivity |
| stint | To be sparing; to restrict in compliance to a share or allowance |
| stipulate | To specify as a condition or obligation of an agreement or offer |
| stratify | To arrange or divide into separate layers |
| strident | Loud, harsh; unpleasantly noisy |
| stymie | To block or thwart; to stump |
| subterranean | Hidden; secret; underground |
| sully | To taint or pollute; to tarnish |
| superfluous | Extra; excess; more than required |
| supersede | To cause to be set aside; to force out of use as inferior, to replace |
| supplant | To replace by force; to take the place of |
| surmount | To conquer or overcome |
| sybarite | A person dedicated to pleasure and luxury |