5 Written Questions
5 Matching Questions
- Describe Adverse Effects of Cefazolin
2A) If they are prodrugs, how activated?
3) Mech and resistance?
3A) Where do they methylate?
5) What is the name of a similar drug? Where does this drug alkylate?
- MOA of trastuzumab
- Trisomy 21 (Down Syndrome)
- What are some Nursing Responsibilities for administering Acycolvir?
- a 1) Dacarbazine, Procarbazine
2A) In the liver.
3) methylate DNA, cause breaks.
3A) O6 of guanine
4) Dacarbazine - myelo/n&v; Procarbazine is very carcinogenic/terato. Bad for fertility, which is relevant b/c used in young people's hodgkin.
5) Temozolomide O6, N7
- b 1/800 live births. 90% are errors in maternal meiosis I, 10% are errors in paternal meiosis II. Sx: hypotonia, flat face, brachycephaly, upslanting palpebral fissures, Congenital HD, duodenal and tracheoesophageal atresia, 15 times greater risk of leukemia. Sources: 95% translocation, 4% robertsonian translocation (14;21). Recurrence risk is only 1% if you've already had one affected kid.
- c binds HER2 --> blocks normal growing
- d Use surgical glove
Infuse over 1 hour
Start therapy as soon as possible
It's a treatment, not a cure
Refrain from sexual intercourse
- e Rash and diarrhea are the most common adverse effects, and superinfections are likely when the antibiotic is used for prolonged periods. Pain and phlebitis can occur at the IM injection site. Anaphylactic response is possible.
5 Multiple Choice Questions
- Loss or gain of extra copy of PMP22 gene due to deletion/insertion due to unequal crossing over, usually male meiosis.
- spaces between two layers of dura in the brain, drainage of the blood from the brain is chiefly into these sinuses - no valves and usually triangular in shape, don't usually collapse because of fibrous dura
- protease - enters PNS and passes into CNS via retrograde axonal transport - enters glycinergic interneurons and inactivates synaptobrevin and stops vesicular release of glycine IRREVERSIBLY - muscle spasms and interference with respiration - reverse with neuromuscular blocking agents and assisted ventilation
- Surrounds neurons in sensory, sympathetic and parasympathetic ganglia to regulate the external chemical environment
- Antifungal activity
5 True/False Questions
Describe the arterial supply to the spinal cord → cerebellar peduncles on dorsal aspect, 4th ventricle in between, corticospinal tract, medial lemniscus
Brodmann's Area 41, 42 → Primary auditory cortex (Superior temporal gyrus)
Brodmann's Area 3, 1, 2 → Primary somatosensory cortex (postcentral gyrus)
Carbachol, nicotine and succinylcholine → nicotinic agonists (nAChRs) - none of these are degraded by AchE in the cleft - prolonged binding and possibility of desensitization of the receptor
Oligodendrocytes → X dom. MECP2. 99% due to spontaneous mutation; 70% in paternal germline. If couple has affected child but no MECp2 mutation, recurrence risk is low. Deceleration of head growth, hand and arm flapping, impaired language development. Sx stabilize and progress without further degradation. male lethal (unless mosaic or klinefelter XXY)