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5 Written Questions

5 Matching Questions

  1. Sustained Levels
  2. What is the difference between a SERM and a SERD?
  3. Beta blockers
  4. mental deterioration
  5. Review the concept of the electrochemical gradient for ionic diffusion across the cell membrane and apply this concept to new conditions
  1. a antagonists of b1 receptors (propranolol) - used to treat hypertension because they antagonize vasoconstriction of NE and its action on HR and ventricular constriction
  2. b if this occurs with either GnRH, LH, FSH, or the androgens, it causes a lack of fertility; levels must be cyclic for fertility to occur
  3. c A SERM is a competitive inhibitor of E binding to the E receptor, and may have agonist or antagonist effects; a SERD works more like a noncompetitive inhibitor - it binds strongly, and inhibits receptor dimerization through sterics. It leads to increased turnover of these receptors, and disrupts their ability to go to the nucleus.
  4. d What is a result of Tay-Sachs disease?
  5. e Electrochemical gradient = Vm - Ex (tells you which way the ions will flow)

5 Multiple Choice Questions

  1. auto. dom. 10-20% of all male breast cancers. Associated with PALB2 and RAD51.
  2. the chances of getting a specific result
  3. A transplant between genetically nonidentical individuals of the same species
  4. Additive toxicity with aminoglycosides and other ototoxic and nephrotoxic drugs.
  5. Feldene

5 True/False Questions

  1. have sickle-cell, but can fight off malariaWhat does it mean when your genotype is SS?


  2. GH has both ___ and ___ effects:

    Its acute effects (mostly metabolic) are ___.

    Its longer term effects (mostly on somatic growth) are ___ and mediated through IGF-1.
    direct, indirect




  3. Log Kill Chemotherapy-kills a constant PERCENTAGE of cancer cells regardless of their size (first order kinetics)
    -can never kill ALL tumor cells
    -# of log kills needed for trtmt depends on # of cancer cells in that patient
    -3 log = 99.9% of cells dead
    -4 logs = 99.99% of cells dead


  4. oxytocinAutosomal recessive. Inability to degrade GM2 ganglioside in lysosomes, leading to neuronal death. Infantile, juvenile and adult onset versions. Sx: cherry red retina spot, no HEXA. More common in Ashkenazi Jews, oi vey! (Bonus: why isn't this disease screened for?)


  5. Class 1 agents cell cycle specificityNO CELL SPECIFICITY: kill both normal & malignant cells to the same extent (radiation, mechlorethamine, carmustine)


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