5 Written Questions
5 Matching Questions
- Sustained Levels
- What is the difference between a SERM and a SERD?
- Beta blockers
- mental deterioration
- Review the concept of the electrochemical gradient for ionic diffusion across the cell membrane and apply this concept to new conditions
- a antagonists of b1 receptors (propranolol) - used to treat hypertension because they antagonize vasoconstriction of NE and its action on HR and ventricular constriction
- b if this occurs with either GnRH, LH, FSH, or the androgens, it causes a lack of fertility; levels must be cyclic for fertility to occur
- c A SERM is a competitive inhibitor of E binding to the E receptor, and may have agonist or antagonist effects; a SERD works more like a noncompetitive inhibitor - it binds strongly, and inhibits receptor dimerization through sterics. It leads to increased turnover of these receptors, and disrupts their ability to go to the nucleus.
- d What is a result of Tay-Sachs disease?
- e Electrochemical gradient = Vm - Ex (tells you which way the ions will flow)
5 Multiple Choice Questions
- auto. dom. 10-20% of all male breast cancers. Associated with PALB2 and RAD51.
- the chances of getting a specific result
- A transplant between genetically nonidentical individuals of the same species
- Additive toxicity with aminoglycosides and other ototoxic and nephrotoxic drugs.
5 True/False Questions
have sickle-cell, but can fight off malaria → What does it mean when your genotype is SS?
GH has both ___ and ___ effects:
Its acute effects (mostly metabolic) are ___.
Its longer term effects (mostly on somatic growth) are ___ and mediated through IGF-1. → direct, indirect
Log Kill Chemotherapy → -kills a constant PERCENTAGE of cancer cells regardless of their size (first order kinetics)
-can never kill ALL tumor cells
-# of log kills needed for trtmt depends on # of cancer cells in that patient
-3 log = 99.9% of cells dead
-4 logs = 99.99% of cells dead
oxytocin → Autosomal recessive. Inability to degrade GM2 ganglioside in lysosomes, leading to neuronal death. Infantile, juvenile and adult onset versions. Sx: cherry red retina spot, no HEXA. More common in Ashkenazi Jews, oi vey! (Bonus: why isn't this disease screened for?)
Class 1 agents cell cycle specificity → NO CELL SPECIFICITY: kill both normal & malignant cells to the same extent (radiation, mechlorethamine, carmustine)