| Term | Definition |
|
Metabolism |
Chemical Reactions that take place in the body is known as ___ |
|
Energy Metabolism |
Chemical reactions that enable cells to obtain and use energy from nutrients |
|
Substrate (reactant) |
A Molecule that enters a reaction |
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Product |
Resulting molecule of a reaction |
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Catabolic |
___ Releases energy through breakdown of complex molecules into simpler ones |
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Anabolic |
___ Requires energy to construct complex molecules from simpler ones |
|
Enzymes |
Biological catalysts that speed up chemical reactions. ___ |
|
Cofactors |
Inorganic substances that must be attached to an enzymes active site |
|
Coenzymes |
Organic molecules derived from vitamins that accept and donate hydrogen ions, electrons, & other molecules |
|
Coupled Reactions |
Chemical reactions that take place simultaneously, often involving the oxidation of one melecule & reduction of the other |
|
Insulin, Glucagon, Cortisol, EPI |
__,__,__,__ are all metabolism regulatory hormones |
|
ATP (provides energy for) |
__ provides energy for Protein synthesis, muscle contractions, active transport, nerve transmission |
|
Substrate Phosphorylation |
___ ___ is when a Phosphate group is added directly to ADP, O2 NOT Required |
|
Oxydative Phosphorylation |
__ __ is when oxydation of NADH + H and FADH2 to phosphorylation of ADP and ATP |
|
Electron Transport Chain |
___ is when electrons are transfered & hydrogen ions from NAHD + H along protein complexes in the inner mitochondrial membrane producing ATP |
|
(Stage 1) Glycogenolysis |
Breakdown of Glycogen for glucose |
|
(Stage 2) Glycolysis |
___ is splitting a 6-carbon glucose into 2 pyruvate, Anaerobic |
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Cori Cycle |
During ___ ___ Glycolysis & Gluconeogenesis, limited O2 availability |
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Citric Acid Cycle |
Aerobic Pathway, Forms GTP & reduced coenzymes |
|
Protein |
Supplies less then 10% of ATP needs, |
|
(Stage 1) Proteolysis |
__ happens during Starvation, Protein->AA, Liver takes AA |
|
(Stage 2) Transamination |
___ is transfer of amino group from an AA to a a-ketoacid is known as ___ |
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(Stage 2) Deamination |
___ is removal of amino group from an amino acid |
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(Stage 3) Protein Catabolism |
___ ___: Citric Acid Cycle, A-ketoacids oxidized to produce NADH + H |
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(Stage) 1st Lipolysis |
Catalyzed by hormone-sensitive lipase from adipose tissue |
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(Stage) 4th Lipolysis |
Molecules of acetyl-CoA from beta oxidation enter citric acid cycle |
|
(Stage) 5th Lipolysis |
Reduced coenzymes enter electron transport chain and create large amounts of ATP |
|
Cytoplasm |
Anabolism takes place in ___ |
|
Glycolysis, Gluconeogenesis, Glycogenesis, Lipogenesis, Ketogenesis, Citric Acid Cycle |
Anabolic Pathways include: __,__,__,__,__,__ |
|
Glycogenesis |
Glycogen formed in liver and muscle from glucose |
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Lipogenesis |
Uptake of excess glucose by adipose tissue, conversion is irreversible |
|
Gluconeogenesis |
Non-carbs transformed into glucose |
|
Gluconeogenesis (via Amino Acids) |
Removal of amino group via transamination and deamination along with conversion of carbon skeleton to oxaloacetate |
|
Ketogenesis |
Metabolic pathway used to produce ketones from acetyl-CoA |
|
Ketones |
Organic substance used as energy during starvation or low carb diets |
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Ketosis |
Ketone production exceeds ketone use |
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Ketoacidosis |
Severe ketosis including low blood pH, nausea, coma |
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1st Absorptive (State) |
___ state Nutrients Enter Blood |
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2nd Absorptive (State) |
____ state stimulates release of insulin |
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3rd Absorptive (State) |
___ state Inhibits release of glucagon |
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4th Absorptive (State) |
Energy metabolism in liver, adipose, skeletal muscle change |
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5th Absorptive (State) |
During ___ATP is produce provided by Glycolysis, citric acid cycle, electron transport chain |
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Post Absorptive State |
4 hours after intake, insulin decrease, glucagon increase, blood glucose decrease, |
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Acute Starvation |
absence of food first 5 days |
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Prolonged Starvation |
Food deprivation longer then 1 week, RBC rely on glucose for ATP production |
|
2nd Lipolysis |
During ___ Fatty acid activated by CoA to its Carboxylic Acid end, transported across mitochondira membrane |
|
3rd Lipolysis |
During ___ 2-carbons cleaved off, forming acetyl-CoA, Repeat. Generates 1 NADH + H and FADH2 |
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Lipolysis |
__ is the breakdown of triglycerides to FA and glycerol |
|
Citric Acid Cycle |
Central Metabolic Pathway oxidazes acetyl-CoA to yield CO2, NADH+H,FADH2, and GTP |
|
Oxidative Phosphorylation |
Coupled process NADH+H,FADH2 are oxidized to NAD,FAD and ADP is phosphorylated to ATP |
|
(Stage 3) Pyruvate |
Direction depends on availability |
|
(Anaerobic Condition) Cori Cycle |
__ __ is a metabolic pathway that involves glycolysis and gluconeogenesis, |
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Aerobic Condition |
Pyruvate combines with coenzyme A to form Acetyl-CoA-->enters citric acid cycle |