| Term | Definition |
|
immunity |
resistance to infection (invasion by a virus, bacteria, fungi, protozoan) |
|
defenses against disease |
nonspecific and specific |
|
nonspecific |
structural & cell mediated |
|
structural |
skin, bacteriostats(fluids), cilia, mucus membrane |
|
cell-mediated |
phagocytic cells (e.g macrophages) surround and destroy ANY foreign matter that causes inflammation |
|
inflammation |
response to tissue damage which causes redness, swelling & warmth at the site due to increase in cells + fluid |
|
specific |
antibody mediated |
|
antibody mediated |
antibody proteins bind to antigens causing clumping and then macrophages destroy the antigens |
|
1798 |
jenner developed the 1st vaccine by injecting a small boy w/ pus from cowpox to protect him vs. smallpox |
|
1860 |
Pasteur developed rabies vaccine |
|
vaccine |
dead/weakened microbes which induce specific immunity vs. the antigen ex. polio, MMR, OPT, flu, HiB, Hep. B |
|
pathogen |
disease causing microbe |
|
specific immunity vs. pathogens |
lymphocytes(WBC produced in bone marrow, travel in blood & lymph systems) and collect in lymph organs(nodes, tonsils, spleen) 2 types; B & T lymphocytes |
|
B cells |
mature in bone marrow & make antibodies w/ protein markers to bind to antigens with the best fit; the plasma cells and memory cells are made |
|
T cells |
mature in the thymus & divided into 3 types |
|
killer T cells |
kill antigens for cell-mediated, also kill tumor cells |
|
helper T cells |
interact w/ B cells to make antibodies |
|
suppressor T cells |
interact w/ B cells to stop antibody production when enough are made |
|
primary immune response |
an exposure causes rapid division of plasma cells into antibodies, takes 7-14 days for max. amt. of antibodies to be made, many of the stim. B cells become memory cells |
|
secondary immune response |
after re-exposure to same antigen memory cells make antibodies in 2-6 days |
|
antibodies location |
serum and lymph and on surfaces of B cells |
|
complement system |
can be activated when antibodies bind to antigens, series of serum proteins |
|
HLA(human leukocyte antigens) |
self proteins that T cells recognize & so they dont react to this = tolerance |
|
cyclosporin |
drug used to suppress immune system (taken for life after transplant) |
|
types of immunity |
inborn and acquired |
|
inborn |
resistance to non-human diseases (ex. TMV) before birth |
|
acquired |
resistance developed after birth; passive & active |
|
passive |
antibodies put in and not in response to antigen, temporary immunity a) natural- from mother to baby through placenta & breast milk b)artifical- injections |
|
active |
antibodies made by the body in response to antigens, more permanent immunity a) natural- antibodies made after infection/disease b) artificial- antibodies made after vaccine of dead/weak antigens are injected |
|
immune system suppressors |
stress, drugs, HIV |
|
allergic reactions |
caused by hypersensitivity (hyperactive immnue response) |
|
poison ivy reaction |
chem. alters HLA and T cells attack own "foreign" cells causing inflammation, rash, blisters from release of histamine |
|
allergens cause- |
constriction of breathing from blocked airways, death |
|
autoimmunity |
antibody or T cells bind to "self" cells due to gene susceptability & environment ex. rheumatoid arthritis, multiple sclerosis, some cancers |
|
viral diseases |
colds, flu, hepatitis, measles, polio, mono, HIV, are caused by the virus reproducing only INSIDE cells (lytic cycle) |
|
bacterial diseases |
cholera, bubonic plague, lyme disease, gonorrhea, syphilis, strep throat, salmonella, tetanus : reproduce by binary fission of the prokaryote |
|
bacteria shapes |
cocci (round), bacilli (rod), sprilli (spiral) named by prefix: diplo(2), staphylo(cluster), strepto(chain) |
|
protozoan diseases |
amoiebic dysentery, African Sleeping Sickness, malaria: caused by 1 celled eukaryotes classified by types of movement |
|
sarcodines |
pseudopodia ex. amoeba |
|
ciliates |
cilia ex. paramecium |
|
flagellates |
flagella ex. euglena |
|
sporozoans |
no means, parasites ex. plasmodium (malaria), trypanosome(African Sleeping Sickness) |
|
prion |
infectious protein in the brain of a CJD patient |