| Term | Definition |
|
Trazodone, Nefazodone |
Antidepressants; Inhibit reuptake of 5-HT, block post-synaptic 5-HT2 receptors (2) |
|
Bupropion |
Antidepressant; Inhibits DA, 5-HT, and NE uptake |
|
Mirtazapine |
Antidepressant; Alpha2 antagonist (increased NE and 5-HT), H1 receptor antagonist |
|
Fluoxetine, Sertraline |
Antidepressants; SSRIs (can inhibit P-450s, anorgasmia) (2) |
|
Venlafaxine, Duloxetine |
Antidepressants; SNRIs (2) |
|
Amitriptyline, Nortriptyline, Imipramine, Desipramine |
Antidepressants; TCAs (4) |
|
Tranylcypromine, Phenelzine, Isocarboxazid |
Antidepressants; MAOIs (nonselective)--Atypical depression (3) |
|
Selegiline |
Antidepressant; MAOI (type b) |
|
Lithium, Valproic acid, Carbamazepine, Lamotrigine |
Antidepressants; For bipolar patients (4) |
|
Phenytoin, Carbamazepine, Oxcarbazepine, Phenobarbital, Gabapentin, Tiagabine, Levetiracetam, Felbamate |
Antiepileptics; For partial and generalized tonic-clonic seizures (8) |
|
Ethosuximide |
Antiepileptic; For absence seizures |
|
Valproic acid, Lamotrigine, Topiramate, Zonisamide |
Antiepileptics; For a variety of seizure types (4) |
|
Lorazepam, Diazepam, Fosphenytoin |
Antiepileptics; For status epilepticus (3) |
|
Vigabatrin, Corticotropin, Prednisone |
Antiepileptics; For infantile spasms (3) |
|
Anakinra |
Immunomodulators; Cytokines and growth factors; Cytokine antagonists; IL-1 receptor antagonist |
|
Terbutaline, albuterol, salmeterol |
Asthma; Bronchodilators; Beta-adrenergic agonists (3) |
|
Ipratropium |
Asthma; Bronchodilators; Muscarinic antagonist |
|
Theophylline, aminophylline |
Asthma; Bronchodilators; Methylxanthines (2) |
|
Beclomethasone, fluticasone, budesonide, prednisone |
Asthma; Anti-inflammatory agents; corticosteroids (4) |
|
Zileuton, zafirlukast, montelukast |
Asthma; Anti-inflammatory agents; Leukotriene pathway modifiers (3) |
|
Cromolyn, nedocromil |
Asthma; Anti-inflammatory agents; release inhibitors (2) |
|
Omalizumab |
Asthma; Anti-inflammatory agents; anti-IgE therapy |
|
Dimenhydrinate, diphenhydramine, meclizine, promethazine, fexofenadine, loratadine |
Autocoids; Antihistamines (6) |
|
Dramamine |
Autocoids; Antihistamines; Dimenhydrinate trade name |
|
Benadryl |
Autocoids; Antihistamines; Diphenhydramine trade name |
|
Antivert |
Autocoids; Antihistamines; Meclizine trade name |
|
Phenergan |
Autocoids; Antihistamines; Promethazine trade name |
|
Allegra |
Autocoids; Antihistamines; Fexofenadine trade name |
|
Claritin |
Autocoids; Antihistamines; Loratadine trade name |
|
Sumatriptan |
Autocoids; Biogenic Amines; Triptans; For migraine use; 5-HT1 agonist |
|
Bismuth subsalicylate (Pepto-Bismol) |
GI drugs; Mucosal protective agent |
|
Cimetidine, Ranitidine |
GI drugs; H2-receptor antagonists (2) |
|
Omeprazole, esomeprazole, rabeprazole |
Proton pump inhibitors (3) |
|
Misoprostol |
GI drugs; Prostaglandin (prostaglandin E1 analog), abortifactant |
|
Metoclopramide |
GI drugs; Prokinetic agent (D2 antagonist, 5-HT3 antagonist, 5-HT4 agonist) |
|
Metoclopramide, chlorpromazine, prochlorperazine, promethazine, droperidol |
GI drugs; Antiemetics; D2 receptor antagonists (5) |
|
Odansetron, granisetron, palonsetron |
GI drugs; Antiemetics; 5-HT3 receptor antagonists (3) |
|
aprepitant |
GI drugs; Antiemetics; Substance P antagonist |
|
Dimenhydrinate |
GI drugs; Antiemetics; H1 antihistamine |
|
Nabilone |
GI drugs; Antiemetics; Cannabinoid |
|
Sulfasalazine, mesalamine |
GI drugs; Inflammatory bowel disease (2) |
|
Cyclosporine, Tacrolimus, Pimecrolimus |
Immunomodulators; Calcineurin inhibitors (3) |
|
Sirolimus, mycophenolate mofetil, leflunomide, thalidomide |
Immunomodulators; Regulators of cytokine response (4) |
|
Azathioprine |
Immunomodulators; Purine analog |
|
Methotrexate |
Immunomodulators; For autoimmune diseases |
|
Glatiramer |
Immunomodulators; Similar to myelin basic protein; for MS |
|
Anakinra |
Immunomodulators; Cytokine antagonist |
|
Leflunomide |
Immunomodulators; Regulators of cytokine response; inhibits dihydroorotate dehyrogenase |
|
Infliximab |
Immunomodulators; Monoclonal antibodies; monoclonal antibody against TNFalpha used to treat Crohns, UC, RA, ankylosing spondylitis |
|
Chlorpromazine, haloperidol |
Typical antipsychotics (2) |
|
Risperidone, Clozapine, Olanzapine, Quetiapine, Ziprasidone |
Atypical antipsychotics (5) |
|
Aripiprazole |
Antipsychotics; Dopamine system stabilizer; Partial agonist at D2 and 5-HT1a; antagonist at 5-HT2a |
|
l-dopa, carbidopa, simemet |
Standard Parkinson's treatments (3) |
|
Selegiline, Rasagiline |
Parkinson's treatment; MOA-B inhibitors (2) |
|
Tolcapone, entacapone |
Parkinson's treatment, COMT inhibitors (prevent L-dopa breakdown in peripheral tissues) (2) |
|
Bromocriptine, pergolide, ropinirole, pramipexole |
Parkinson's treatment, Dopamine agonists (4) |
|
Benztropine, trihexyphenidyl |
Parkinson's treatment, centrally acting antimuscarinic agents (block muscarinics within the striatum) (2) |
|
Amantadine |
Parkinson's treatment; dopamine releasing agent |
|
Donepezil, rivastigmine, galantamine, tacrine |
Alzheimer's treatment; acetylcholinesterase inhibitors (4) |
|
Memantine |
Alzheimer's treatment; NMDA receptor agonist |
|
zaleplon (sonata) |
Hypnotic that decreases latency to sleep (~4 hr duration of action) and is approved for short term use, but has not anxiolytic or muscle relaxant properties |
|
carbamazepine, felbamate, valproic acid |
Antiseizure drugs; Liver function test required by the FDA (3) |
|
Modafinil |
Non-amphetamine stimulant clinically used to treat Narcolepsy |
|
Venlafaxine, Duloxetine |
Antidepressants; block norephinephrine uptake as well as serotonin uptake |
|
Sildenafil |
Autocoids; Prostaglandins; Trade name Viagra |
|
Cimetidine, Ranitidine |
GI drugs; H2-receptor antagonist (2) |
|
Omeprazole, Esomeprazole, Rabeprazole |
GI drugs; Proton pump inhibitors (3) |
|
Diphenoxylate, loperamide, bismuth subsalicylate, alosetron |
GI drugs; Antidiarrheal (4) |
|
Tegaserod, Lubiprostone |
GI drugs; Laxatives and stool softeners (2) |
|
Bran, Psyllium preparations, methylcellulose |
GI drugs; Bulk Laxatives (3) |
|
Milk of magnesia, sodium phosphate, glycerin, lactulose, polyethylene glycol, ascorbic acid |
GI drugs; Osmotically active agents (6) |
|
Bisacodyl, cascara sagrada, senna, castor oil |
GI drugs; Stimulant laxatives (4) |
|
phenobarbital, pentobarbital, thiopental |
Sedative-hypnotics; Barbiturates (3) |
|
Chlordiazepoxide, diazepam, flurazepam |
Sedative-hypnotics, Benzodiazepines, long half-life (3) |
|
Lorazepam, temazepam, alprazolam |
Sedative-hypnotics; Benzodiazepines; medium half-life (3) |
|
Midazolam |
Sedative-hypnotics; Benzodiazepine; short half life |
|
Flunitrazepam, clonazepam |
Sedative-hypnotics; Benzodiazepines; other (2) |
|
Zaleplon, Zolpidem, Eszopiclone |
Sedative-hypnotics; Non-benzodiazepines (z-drugs); bind to BZ1 subtype of benzodiazepine sites (3) |
|
Flumazenil |
Sedative-hypnotics; Non-benzodiazepines (z-drugs); benzodiazepam site antagonist |
|
Chloral hydrate, meprobamate |
Sedative-hypnotics; Older sedative-hypnotics |
|
Melatonin, Ramelteon |
Sedative-Hypnotics; Melatonin receptor agonists |
|
Buspirone |
Sedative-hypnotic; Serotonergic agent; agonist at 5-HT1a |
|
Diphenhydramine, doxylamine |
Sedative-hypnotics; Over-the-counter sleep aids; Antihistamines |
|
Baclofen, Tizanidine, Dantrolene |
Sedative-hypnotics; Spasmolytics |
|
Baclofen |
Sedative-hypnotics; Spasmolytic; GABAb receptor agonist |
|
Tizanidine |
Sedative-hypnotics; Spasmolytic; central alpha2 receptor agonist |
|
Hydromorphone, methadone, meperidine, fentanyl, oxycodone, loperamide, naloxone, naltrexone, buprenorphine, dextromethorphan |
Synthetic opiates (10) |
|
Hydromorphone |
Synthetic opiate; more potent than morphine |
|
Meperidine |
Synthetic opiate; less potent and shorter duration than morphine |
|
Loperamide |
Synthetic opiate; controls diarrhea |
|
Buprenorphine |
Synthetic opiate; partial agonist at opiate receptors, antagonizes morphine and heroin |
|
Dextromethorphan |
Synthetic opiate; cough suppressant |
|
Methotrexate, Gold, leflunomide, etanercept, infliximab, abatacept, rituximab, anakinra |
Inflammation; Disease-modifying anti-rheumatic drugs (8) |
|
NSAIDs |
Aspirin, ibuprofen, naproxen, salicylate, celecoxib |
|
Acetaminophen, Glucocorticoids |
Inflammation; others (2) |
|
Indomethacin, colchicine, phenylbutazone |
Gout; Anti-inflammatory (3) |
|
Allopurinol, febuxostat |
Gout; Decreased production (inhibit xanthine oxidase) (2) |
|
Probenecid, sulfinpyrazone |
Gout; Uricosuric drugs |
|
Daclizumab, basiliximab, muromonab, abatacept |
Immunomodulators; monoclonal antibodies used to treat inflammatory disorders (4) |
|
cocaine, amphetamines, phenethylamine, phenylpropanolamine, kathionine |
Stimulants; CNS sympathomimetics (5) |
|
methylphenidate, atomoxetine |
Stimulants; ADHD treatments (2) |
|
Modafinil, gamma hydroxybutyrate |
Stimulants; Narcolepsy treatments (2) |
|
Dronabinol, Rimonabant |
Similar to marijuana (2) |
|
Fomepizole, Disulfiram, Naltrexone, Acamprosate |
Alcohol treatments (4) |
|
Propranolol, Methysergide, Amitriptyline, verapamil, valproic acid, topiramate, gabapentin, ibuprofen |
Prophylactic treatments for migraine (8) |
|
PPI/H2Ra, metronidazole, tetracycline, bismuth subsalicylate |
GI drugs, Antimicrobial agents, Quadruple drug therapy |