Quizlet
or
There are no sets in this subject.
No groups found.
| azathioprine definitions | |||
|---|---|---|---|
| # | Definition | Sets | |
| 1 | imuran | 14 sets | |
| 2 | immunosuppressant | 3 sets | |
| 3 | prodrug activated by enzymes to 6-thiol-mp blocking purine synthesis pathway suppressing b&t cells; used for autoimmune disorders (hemolytic anemia) and kidney transplantation **shouldn't be used with allopurinol (blocks breakdown of drug by inhibiting xanthine oxidase) | 2 sets | |
| 4 | asazan | 2 sets | |
| 5 | immunomodulators, purine analog | 2 sets | |
| 6 | a pro-drug –metabolised to give 6-mercaptopurine (antimetabolite)that inhibits dna synthesis –suppresses cell-mediated and antibody-mediated immune reactions lymphocytes are predominantly affected by azathioprine cytotoxic effect side effects: bone marrow suppression nausea and vomiting | 1 set | |
| 7 | bone marrow suppression. careful when using xanthine oxidase | 1 set | |
| 8 | prodrug of 6-mercaptopurine/ immunosuppresive agent/antimetabolite of the de novo purine nucleotide biosynthesis/ "mixed" carrier-linked/bioprecursor prodrug - enzymatically activated | 1 set | |
| 9 | cytotoxic drug affecting t-cells more than bmoa- s-phase inhibitor: converted to thioinosinic acid (competitive inhibitor)uses: organ transplants, rheumatoid artheritistoxicity: myelosuppression, gi, hepato, severe infection, mutagenesis and cancer (skin)drug interactions: allopurinol may increase toxicity | 1 set | |
| 10 | maintenance | 1 set | |
| 11 | imuran,, antimetabolite precursor of 6-mercaptopurine that interferes witht he metabolism and synthesis of nucleic acids. toxic to proliferating lymphocytes. used for kindney transplantation, autoimmune disorders (including glomerulonephritis and hemolytic anemia). toxicity: bone marrow suppression. active metabolite mercaptopurine is metabolized by xanthine oxidase; thus, toxic effects may be increased by allopurinol. | 1 set | |
| 12 | 1) inhibits both dna and rna synthesis(suppresses de novo purine synthesis. 2) it has effects on both b and t lymphocytes. 3) anti-inflammatory effect | 1 set | |
| 13 | incorporated into dna inhibiting further dna synthesis | 1 set | |
| 14 | dmards - cytotoxic - antimetabolites: purine antmetabolite, derivative of 6- mercaptopurine, inhibit de novo purine synthesis | 1 set | |
| 15 | metabolized to 6-mercaptopurine. suppresses rejection during organ transplantation. | 1 set | |
| 16 | used in combination with corticosteroids for immunosuppression. converted to a competative inhibitor if inosinic acid (precursor to a and g); therefore, it blocks the cell cycle in the s phase. coadministration of allopurinol can increase toxicity effects (in the gi, bone marrow, and liver). | 1 set | |
| 17 | imuran; asazan | 1 set | |
| 18 | antimetabolites | 1 set | |
| 19 | what immunosuppressive agent is converted to 6-mercaptopurine? imuran, prodrug activated by enzymes to 6-thiol-mp blocking purine synthesis pathway suppressing b&t cells; used for autoimmune disorders (hemolytic anemia) and kidney transplantation **shouldn't be used with allopurinol (blocks breakdown of drug by inhibiting xanthine oxidase) | 1 set | |
| 20 | antiproliferative agents | 1 set | |
| 21 | what immunosuppressive agent is converted to 6-mercaptopurine? | 1 set | |
| 22 | antimetabolite that is converted to 6-mp, inhibiting de-novo purine synthesis | 1 set | |
| 23 | leads to suppression of b and t cells, ig production and il-2 secretion | 1 set | |
| 24 | metabolized to 6-mercaptopurine which suppresses immune rejection used during organ transplantation | 1 set | |
| 25 | immunomodulators; purine analog | 1 set | |
| 26 | this drug is activated by hgprt, and broken down by xanthine oxidase | 1 set | |
| 27 | metabolized into 6-mercaptopurine, suppresses inosinic acid synthesis and b,t-cell function | 1 set | |
| 28 | antimetabolite precursor of 6-mercaptopurine that interferes witht he metabolism and synthesis of nucleic acids. toxic to proliferating lymphocytes. used for kindney transplantation, autoimmune disorders (including glomerulonephritis and hemolytic anemia). toxicity: bone marrow suppression. active metabolite mercaptopurine is metabolized by xanthine oxidase; thus, toxic effects may be increased by allopurinol. | 1 set | |