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| leflunomide definitions | |||
|---|---|---|---|
| # | Definition | Sets | |
| 1 | antirheumatic, immunosupressive; inhib dihydroorotate dh -> inhib pyrimidine synth, inhib tcell prolif, : ade: diarrhea, rash, alopecia, hepatotox; ci: pregnancy, liver dz | 2 sets | |
| 2 | immunomodulators, regulators of cytokine response, inhibits dihydroorotate dehydrogenase | 2 sets | |
| 3 | arava | 2 sets | |
| 4 | treatment of dmards, inhibit dihydroorotate dehydrogenase by active metabolite a77-1726, inhibit pyrimidine biosynthesis, decrease ump | 1 set | |
| 5 | hepatic dysfunction | 1 set | |
| 6 | inhibit mitochondrial dihydroorotate dehydrogenase | 1 set | |
| 7 | inhibits dhodh, decreasing levels of ump, leading to inhibition of t-cell proliferation and b-cell autoantibody production | 1 set | |
| 8 | arava contraindicated in pregnancy, diarrhea, elevated liver enzymes, alopecia and rash | 1 set | |
| 9 | inflammation, disease-modifying anti-rheumatic drugs (dmards), immunosuppresive agents | 1 set | |
| 10 | antiproliferative agents | 1 set | |
| 11 | moderate to severe rheumatoid arthritis and psoriasis arthritis | 1 set | |
| 12 | immunomodulators; regulators of cytokine response; inhibits dihydroorotate dehyrogenase | 1 set | |
| 13 | inhibits dihydroorotate dh, leading to decrease in de novo pyrimidine synthesis. specific for t, b cells since they only rely on de novo creation. | 1 set | |