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| methotrexate definitions | |||
|---|---|---|---|
| # | Definition | Sets | |
| 1 | methotrexate | 10 sets | |
| 2 | rheumatrex | 5 sets | |
| 3 | - | 5 sets | |
| 4 | trexall | 3 sets | |
| 5 | rheumatrex, trexall | 3 sets | |
| 6 | cancer | 3 sets | |
| 7 | treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis | 3 sets | |
| 8 | inhibits dihydrofolate reducatase (dhfr), rheumatrex, antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases such as ankylosing spondylitis, crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis. | 2 sets | |
| 9 | mexate | 2 sets | |
| 10 | no brand name | 2 sets | |
| 11 | anntimetabolite | 2 sets | |
| 12 | immunomodulators, autoimmune diseases | 2 sets | |
| 13 | no trade | 2 sets | |
| 14 | long/short-term tx of cd pts, may be useful in long-term tx of uc pts, possible steroid sparing effects | 2 sets | |
| 15 | folex | 1 set | |
| 16 | t: dihydrofolate reductase a: competitive inhibition blocks one-carbon transfer reactions, reducing methylation of uridine to thymine, decreasing dna synthesis acute lymphoma leukemia, choriocarcinoma and other tumors, severe psoriasis altered dhfr, increased dhfr synthesis, drug efflux myelosuppresion, mucositis administration of folinic acid reuces toxicity due to selective uptake by normal cells | 1 set | |
| 17 | an example of an antimetabolite is | 1 set | |
| 18 | folate analog | 1 set | |
| 19 | liver fibrosis, fatty change | 1 set | |
| 20 | a drug used in some medical abortions | 1 set | |
| 21 | antifolate/inhibitor of dihydrofolate reductase (dhfr)/ bioprecursor prodrug - enzymatically activated ??? | 1 set | |
| 22 | med used for head, neck, or lung carcinoma | 1 set | |
| 23 | cancer therapy and dmards, used for rheumatoid arthritis, inhibits aicar transformylase and adenosine deaminse and amp deaminase, inhibit last step in de novo purine biosynthesis | 1 set | |
| 24 | ra tx: **started w/in 3 months of diagnosis**, give with folic acid. toxicity: gi/pulmonary/hypersensitivity/bone marrow supression, hepatic fibrosis. monitor: immunosupression/sob/cough/doe/n/v/lymph node swelling/jaundice/dark urine *** lft's/createnine q 4-8 weeks, platelet count. avoid: bactrim, nsaids, etoh | 1 set | |
| 25 | antifolate & antimeabolite - interrupt normal cell function especially in rapidly replicating cells; inhibits dihydrofolate reductase—inhibiting the formation of thfa ; folate supplement is given 5mg/day | 1 set | |
| 26 | this antineoplastic drug can cause oral ulcers | 1 set | |
| 27 | competitive inhbitors of dna synthesis in the s phase | 1 set | |
| 28 | myelosuppression and mucositis | 1 set | |
| 29 | rhematrex; antineoplastic agent; cancer, ra | 1 set | |
| 30 | antimetabolite, folate antagonist, enteres via active transport and inhibits folate synthesis, inhibits conversion of dihydrofolate to thfr, to depletion of thymidine, and decrease in dna/rna and protein. also becomes polyglutamated and accumulates in cells and increases inhibitory effects on enzymes involved in folate metabolism and increase in duration of action | 1 set | |
| 31 | && | 1 set | |
| 32 | trexall, rheumatrex | 1 set | |
| 33 | tx of leukemia, lymphoma, breast cancer, osteosarcoma, testicular tumors | 1 set | |
| 34 | inhibits t-cell proliferation by binding dihydrofolate reductase to stop tmp production | 1 set | |
| 35 | preventive immunosuppressant for agvhd (antiproliferative) | 1 set | |
| 36 | dmard; treat autoimmune and cancer (1st line for rheumatoid arthritis); inhibits folic acid pathway; inhibits dna and rna synthesis | 1 set | |
| 37 | to reverse the toxicity of this antimetabolite, purines, thimidine and reduced folates need to be administered. | 1 set | |
| 38 | this antimetabolite is a folic acid antagonist. | 1 set | |
| 39 | name a folic acid antagonist | 1 set | |
| 40 | drug used to inhibit cell division and enlargement of emryo during an ectopic pregnancy | 1 set | |