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| methotrexate definitions | |||
|---|---|---|---|
| # | Definition | Sets | |
| 1 | methotrexate | 9 sets | |
| 2 | - | 5 sets | |
| 3 | rheumatrex | 5 sets | |
| 4 | treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis | 3 sets | |
| 5 | rheumatrex, trexall | 3 sets | |
| 6 | trexall | 3 sets | |
| 7 | cancer | 3 sets | |
| 8 | immunomodulators, autoimmune diseases | 2 sets | |
| 9 | no trade | 2 sets | |
| 10 | inhibits dihydrofolate reducatase (dhfr), rheumatrex, antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases such as ankylosing spondylitis, crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis. | 2 sets | |
| 11 | long/short-term tx of cd pts, may be useful in long-term tx of uc pts, possible steroid sparing effects | 2 sets | |
| 12 | no brand name | 2 sets | |
| 13 | anntimetabolite | 2 sets | |
| 14 | med used for head, neck, or lung carcinoma | 1 set | |
| 15 | rhematrex; antineoplastic agent; cancer, ra | 1 set | |
| 16 | folate analog | 1 set | |
| 17 | trexall, rheumatrex | 1 set | |
| 18 | antimetabolite, folate antagonist, enteres via active transport and inhibits folate synthesis, inhibits conversion of dihydrofolate to thfr, to depletion of thymidine, and decrease in dna/rna and protein. also becomes polyglutamated and accumulates in cells and increases inhibitory effects on enzymes involved in folate metabolism and increase in duration of action | 1 set | |
| 19 | ra tx: **started w/in 3 months of diagnosis**, give with folic acid. toxicity: gi/pulmonary/hypersensitivity/bone marrow supression, hepatic fibrosis. monitor: immunosupression/sob/cough/doe/n/v/lymph node swelling/jaundice/dark urine *** lft's/createnine q 4-8 weeks, platelet count. avoid: bactrim, nsaids, etoh | 1 set | |
| 20 | this antineoplastic drug can cause myelosuppression, nausea, and vomiting, and can accumulate via 3rd space accumulation | 1 set | |
| 21 | disease modifying anti rheumic, mono or with other drugs, ae nausea headache, stomahitis | 1 set | |
| 22 | therapeutic >0.01 µmol ; toxic >10µmol in 24hr | 1 set | |
| 23 | mtx | 1 set | |
| 24 | this antineoplastic drug can cause oral ulcers | 1 set | |
| 25 | antifolate & antimeabolite - interrupt normal cell function especially in rapidly replicating cells; inhibits dihydrofolate reductase—inhibiting the formation of thfa ; folate supplement is given 5mg/day | 1 set | |
| 26 | mexate | 1 set | |
| 27 | competitive inhbitors of dna synthesis in the s phase | 1 set | |
| 28 | cancer therapy and dmards, used for rheumatoid arthritis, inhibits aicar transformylase and adenosine deaminse and amp deaminase, inhibit last step in de novo purine biosynthesis | 1 set | |
| 29 | t: dihydrofolate reductase a: competitive inhibition blocks one-carbon transfer reactions, reducing methylation of uridine to thymine, decreasing dna synthesis acute lymphoma leukemia, choriocarcinoma and other tumors, severe psoriasis altered dhfr, increased dhfr synthesis, drug efflux myelosuppresion, mucositis administration of folinic acid reuces toxicity due to selective uptake by normal cells | 1 set | |
| 30 | myelosuppression and mucositis | 1 set | |
| 31 | a drug used in some medical abortions | 1 set | |
| 32 | anti-metabolites: folate analogue, blocks synthesis of dna bases through dhfr | 1 set | |
| 33 | dmard | 1 set | |
| 34 | rheumatrex, , toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid | 1 set | |
| 35 | aka mexate, folex; antimetabolite (for chemotherapy); folic acid analog inhibits dihydrofolate reductase, which inhibits dna synth; used for ra, psoriasis, leukemia, lymphoma ades = myelosuppression | 1 set | |
| 36 | ra, 1st line tx!. dihydrofolate reductase inhibitor (interrupt dna synthesis). usually given in small weekly oral dose 7.5 mg. adr: nausea, mucosal ulcer, hepatoxicity, leucovorin (24 hr after pulse) | 1 set | |
| 37 | anticancer drug that competes with folate | 1 set | |
| 38 | folate antagonists--inhibits dhfr; (dna synthesis inhibitor) causes myelosuppression at 4-7 days, mucositis, acute renal failure; can save pt with leucocorin | 1 set | |
| 39 | to reverse the toxicity of this antimetabolite, purines, thimidine and reduced folates need to be administered. | 1 set | |
| 40 | this antimetabolite is a folic acid antagonist. | 1 set | |