Flashcard sets with a 'methotrexate' term meaning 't: dihydrofolate reductase a: competitive inhibition blocks one-carbon transfer reactions, reducing methylation of uridine to thymine, decreasing dna synthesis acute lymphoma leukemia, choriocarcinoma and other tumors, severe psoriasis altered dhfr, increased dhfr synthesis, drug efflux myelosuppresion, mucositis administration of folinic acid reuces toxicity due to selective uptake by normal cells'

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