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6110- appraisal of an RCT study
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Terms in this set (19)
target population
inclusion/exclusion criteria
randomization
pre outcome measures
treatment group/control group
post outcome measures
RCT design (6)
random error/noise
bias
Potential sources of error (2)
true measurement
scale gives value above/below (stand.dev.)
random error/noise
systemic deviation from true value
non random
bias
selection bias
performance bias
detection bias
attrition bias
reporting bias
Types of bias (5)
are the results valid
what are the results
are the results applicable
appraisal framework
assessing RISK of bias
subjective
important for strength of evidence
are the results valid
approx average distance between mean and individual values
measures variability
larger SD = noisy data
standard deviation
range above and below mean
any value outside of CI is significantly different from mean
usually 95% CI or p = 0.05
Confidence interval
T test
ANOVA
ANCOVA
statistical significance tests (3)
used to compare 2 groups
intra or inter comparison
T Test
used with >2 groups
needs additional testing
ANOVA
adjusts for difference that may be present at baseline
best statistical method to incorporate
ANCOVA
measures magnitude of treatment effect
effect size
external reference used to determine significance clinically
clinical significance
standard error of measurement
minimal detectable change
minimally clinically important difference
clinical significance measurements (3)
index of reliability of the outcome measure
standard error of measurement
Minimum change that can be detected by a measure that corresponds to noticeable change in ability
minimal detectable change
amount of change in outcome measure needed to be meaningful
based on clients rating of improvement
strongest indicator of CS
can be specific to clinical population
Minimal clinically important difference
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