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Immune Deficiency Disorders

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Primary Immune Deficiencies
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Terms in this set (27)
Primary Immune Deficiencies
-Present at birth and are a result of a genetic abnormality (inherited or mutation)
-5 catergories
1: Cellular Immune Deficiency (thymus is absent)
2: Humoral Immune Deficiency
3: Combined Immune Deficiency
4: Phagocytic Deficiencies
5: Complement Deficiencies
Secondary Immune Deficiencies
-Occur sometime after birth
-Caused by natural or artificial factors
-Examples include extreme illness, infectious disease or immunosuppressive drugs
Cellular Immune Function Tests
-Peripheral Lymphocyte count
-T cell count (CD4:CD8 ratios will be affected)
-Delayed Hypersensitivity skin testing (90% of adults will react to common antigens but patients with CID will not react)
-Measurement of lymphokine production
-Biopsy of lymph nodes (they are decreased in size and do not contain normal numbers of T lymphs)
Humoral Immune Function Tests
-Immunoglobin (antibody) quantification and typing
-Isohemagglutinin titres (Anti-A and Anti-B) but do typing 1st
-Antibody titres before and after immunization with vaccine
-B cell count by flow cytometry (Antibodies and B cells will be decreased in HID)
-Biopsy of bone marrow and lymph nodes
Thymic Hypoplasia (DiGeorge Anomaly)
-Primary
-Cellular Immune Deficiencies
-Thymus and parathyroid do not develop normally
-Hypocalcemic due to lack of PTH
-Decreased numbers of T cells (function may be normal) and Increased B cells (lymphopenia)
-Treatment with gammaglobulins and patient`s require CMV negative irradiated blood products