Create an account
What are some peptide antibiotics?
What is the activity and spectrum of the Glycopeptides?
-Inhibitors of cell wall synthesis
-Both time- and concentration-dependent
-Only Gram+ (both aerobes and anaerobes)
What are the pharmacokinetics and toxicity issues with Glycopeptides?
- Poorly absorbed orally => IV
- Mainly renal elimination
- Marked tissue toxicity
What are some usages for Glycopeptides?
- No reliable evidence for dosages and/or efficacy in
- Banned in Food Animals
- NEVER to be used empirically
- NOT a first line antibiotic
- Should be used as a last resort for multi-resistant
Gram+ infections in veterinary medicine AFTER
culture & sensitivity testing and if & only if no
What is the activity and spectrum of the Polymyxins?
-Disruptor of cell membranes + Endotoxin effect
-Only Gram- (both aerobes and anaerobes)
What are the pharmacokinetics and toxicity issues with Polymyxins?
-Not absorbed orally, give IV
-Slow renal elmination (nephrotoxicity)
-Nephrotoxicity and neurotoxicity when used systemically
What are the usages of Polymyxins?
-Local use (otitis, dermatitis)
-Systemic use-at low doses for endotoxin activity
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together