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5 Written questions

5 Matching questions

  1. Mechanism of yellow fever hemorrhagic sequelae
  2. 6 vectorborne virus is endemic to the US
  3. viruses that spread via the urban cycle transmission pattern
  4. 4 predominant syndromes caused by viruses transmitted by animals
  5. Pathogenesis of Arboviruses
  1. a Western equine encephalitis
    Eastern equine encephalitis
    St. Louis encephalitis
    California Bunyaviruses (including La Crosse encephalitis)
    Colorado tick fever
    West Nile virus
    -sometimes the Venezuelan equine virus is also seen in the US
  2. b Liver disrupts production of clotting factors leading to bleeding
    -black vomit can also be seen
  3. c -Encephalitis
    - fever with uremic syndrome
    -pulmonary syndrome
    -hemorrhagic fever
  4. d -Yellow fever
    -dengue fever
    -St. Louis encephalitis
  5. e -Introduced into the bloodstream by infected insects
    -viral replication in reticuloendothelial system in vascular epithelium
    -secondary viremia can seed target organs

5 Multiple choice questions

  1. chikungunya= Clicking joint disease (found in Africa and the Indian Ocean islands)
  2. Eosinophilic cytoplasmic inclusion body found in nerves and characteristic of rabies
  3. -Mosquito bites human
    - virus enters bloodstream and replicates in local endothelial cells
    -secondary viremia seeds CNS
    -virus replicated in neurons and meninges
    -symptoms occur due to cell death and inflammation
  4. The incidence of infection is much higher than the number of people that develop clinical symptoms
    -for every person that develops West Nile encephalitis there are approximately 150 people who are infected
  5. 1. Patient gets bitten by and in fact dead skunk, Fox, bat, raccoon, dog, cat
    2. virus replicates in muscle tissue at the site of the bite and spread to local nerve cells
    3. travels via retrograde transport to CNS and replicates in the gray matter virus
    4. virus will also spread to salivary glands via nerves

5 True/False questions

  1. dead end or incidental hostsThe incidence of infection is much higher than the number of people that develop clinical symptoms
    -for every person that develops West Nile encephalitis there are approximately 150 people who are infected

          

  2. Number of known survivors from rabies1

          

  3. diagnosis of insect vector diseases1. Cultures are available for most of the Arboviruses
    -not routine
    -may involve inoculation of newborn mice
    2. diagnosis is usually made by serology using acute and convalescent sera
    -obtaining a sample can be troublesome
    -blood only contains virus during viremia
    -stool is negative
    -viruses rarely found in the throat or CNS
    3. PCR looks promising

          

  4. Viruses primarily seen in people who have traveled outside of the USYellow fever and dengue fever
    -it is important to take a good travel history as part of your exam
    -also consider recommending vaccines for people traveling to specific areas around the globe

          

  5. Complexities of arboviruses-Introduced into the bloodstream by infected insects
    -viral replication in reticuloendothelial system in vascular epithelium
    -secondary viremia can seed target organs

          

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