Chapter 7 Homework
Terms in this set (6)
The first protein structure to
have its structure determined was myoglobin from sperm whale. Propose an explanation for the observation that sperm whale muscle is a rich source of this protein.
Obviously whales are marine creatures that need a very effective way of transporting oxygen efficiently in the tissues since it only comes up for air 1 an hour.
The pKa of an acid depends partly
on its environment. Predict the effect of each of the following
environmental changes on the pKa of a glutamic acid
(a) A lysine side chain is brought into proximity.
(b) The terminal carboxyl group of the protein is brought
(c) The glutamic acid side chain is shifted from the outside
of the protein to a nonpolar site inside.
B- slightly increases
C- increases due to polarity
Hemoglobin A inhibits the formation of the long fibers of hemoglobin S and the subsequent sickling of the red cell on deoxygenation. Why does hemoglobin A have this effect?
Deoxy Hb A contains a complimentary site so it can add on to a fiber of deoxy Hb S. te fiber cannot grow further because the terminal deoxy Hb A molecule lacks a sticky patch.
After spending a day or more
at high altitude (with an oxygen partial pressure of 75 torr),
the concentration of 2,3-bisphosphoglycerate (2,3-BPG) in
red blood cells increases. What effect would an increased
concentration of 2,3-BPG have on the oxygen-binding
curve for hemoglobin? Why would this adaptation be beneficial
for functioning well at high altitude?
This causes the 2,3 to bind more tightly to the hemoglobin stabilizing the T state even better. This then will cause the graph to shift to the right because the R state will be less favored so O2 will be better delivered to tissues.
How does lobster blood work if it uses 2 copper molecules to bind to O2?
The when the copper of one molecule binds to the oxygen the histidine move together causing the helicies to shift causing an effect.
When P. falciparum lives inside red
blood cells, the metabolism of the parasite tends to release
acid. What effect is the presence of acid likely to have on the
oxygen-carrying capacity of the red blood cells? On the
likelihood that these cells sickle?
Acidity makes the oxygen affinity decrease. More cells in T state increases chances of sickled cells.
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