26 terms

The people responsible for finding DNA structure

Who were the people responsible for finding DNA's structure
Francis Crick, Rosalind Franklin, Linus Pauling, James Watson, and Maurice Wilkins
What was Rosalind Franklins life span
1920- 1958
Rosalind Franklin had a graduate in what
Physical Chemistry
Rosalind Franklin had been working sense 1947 on X- ray what at what labs
crystallographic methods at the Central State Chemistry Labs in Paris
Because of Rosalind Franklins skills in X-ray crystallography who hired her and why
John Randall , of the Medical Research Council Biophysics Research Unit at King's College, London. To work on an X- ray picture of DNA taken by a graduate student Raymond gosling
Why didn't the working relationships get off to a good start at King's College
Because Rosalind took all the DNA work and tried to finish it herself. This was not the way the previous scientist, Maurice Wilkins, was running the DNA lab
what was Maurice Wilkins life span
1916- 2004
what were the four things that had to come together for them to model the structure of the DNA
- The Phosphate backbone is on the inside bases on the inside
- The molecule is a double helix
- The strands are Anti parallel
- It has specific base pairings
How did Rosalind figure out some of the problem
She bundled super thin strands of DNA and zapped them with a super fine X-ray beam that resulted in two forms of hydration
what were the two forms of hydration and what did it mean
- The A form(easy to photograph) was dry
- The B form(hard to photograph) was wet
What did Rosalind find out from the B form
Since there was a fuzzy cross in the photograph, there was a double helix. and since the water would be attracted to the phosphates in the backbone, and the DNA was easily hydrated and dehydrated, she guessed the backbone was on the outside and the bases were on the inside
Who was James Watson
A zoology graduate that was present in Franklin's speech in 1951 and was on a National Foundation of Infantile Paralysis Fellowship at Cambridge. he was born in 1928, and working under Laurence Bragg and his X-ray team
After the seminar in 1951 Watson went to Cambridge to meat Crick to make a model DNA they invited Franklin and Wilkins for them to point out what flaws of the model
it was a triple Helix and the bases were on the outside because of this Braggs banned them from doing it again
what was Linus Pauling's part in 1953
he sent his son Peter who was studying at Cambridge a copy of his paper on DNA for comment. Watson new Peter and took the paper to Franklin who dismissed it
What happened in February 1953 dealing with Max Perutz
Max Perutz, head of the Medical Research Council Unit housed at the Cavendish Laboratory in Cambridge received a government report that contained the data presented by Franklin at her departmental seminar. the report was not confidential but private and Perutz passed the report to Crick without asking Randall or franklin's permission
according to Franklin's data she had applied the double helix aspect to which form
the A form if she applied it to the B form she would have solved more of the puzzle
why did Watson and Crick get credit for the info
because the compiled the info and raced to publish it first, Franklin didn't realize this
what was the Watson and Crick paper entitled
A structure for Deoxyribose Nucleic Acid written on the 2nd of April 1953
in ____ year watson and Crick received the Nobel prize in what
1962, physiology or medecine
what happened in the Nobel lectures
they gave 98 references none of which were Franklin, only Wilkins included her in his acknowledgements
when did watson and Crick publish
18th of March 1953
the last part of the puzzle required a thorough knowledge of what
Chargaff's rules
when did Franklin graduate
what had Franklin made original and essential contributions to
understanding of the structure of graphite and other carbon compounds
when and why did Franklin die
age 37 due to cancer
what is X-ray crystallography
the mapping of locations of atoms in any crystal under an X-ray beam