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endochondral ossification involves the creation of osseous tissue out of models in the developing embryo made of this
upon conversion of the perichondrium to periosteum the underlying mesenchymal cells specialize into this
step 1: the cartilage model periosteum secretes this substance which helps form the bone collar
step 2: as the bone collar forms chondrocytes in the cartilage shaft begin to _________, signaling the surrounding matrix to caclify
step 2: the impermeableness of calcified chondrocytes causes the chondrocytes to _____ which cause the hyaline shaft to form _____
step 2: cartilage remains healthy in _____ portions of the hyaline model resulting in the continued _____ of the model
artery, vein, lymphatic vessels, osteoblasts/osteoclasts, nerve fibers, red marrow elements
contents of the periosteal bud
osteoclasts osteoblasts osteoid
step 3: the entering _____ begin to erode much of the calcified cartilage matrix and the _______ secrete _____ around the remaining fragments of cartilage
step 3: the secretion of osteoid around the remaining calcified cartilage fragments creates this
osteoclasts medullary cavity
step 4: _____ break up the newly created spongy bone and form the _______ w/in the center of the shaft
epiphyses elongate ossification cartilage
step 4: throughout the fetal period the _____ remain as hyaline cartilage and thus continue to ______ the bone model and thus _____ chases _____ formation along the length of the shaft
secondary ossification center
step 5: a _________ forms in each epiphysis at the start of epiphyseal ossification
calcifies periosteal bud
step 5: the cartilage in the center of the epiphysis ______ and deteriorates, opening up cavities which allow a _____ to enter
spongy bone medullary cavity
step 5: mimics the ossification process which occured in the diaphysis with the exception that the _____ is retained and no ________ forms
name for cartilage left on the epiphyseal surface after endochondral ossification
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