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hyaline cartilage

endochondral ossification involves the creation of osseous tissue out of models in the developing embryo made of this

primary ossification center

the site in the cartilage shaft where endochondral ossificatin begins


when the perichondrium of the cartilage model becomes vascularized in converts into this


upon conversion of the perichondrium to periosteum the underlying mesenchymal cells specialize into this

bone collar forms around the diaphysis area

the first step of endochondral ossification


step 1: the cartilage model periosteum secretes this substance which helps form the bone collar

cartilage in diaphysis area calcifies and cavitates

the second step of endochondral ossification


step 2: as the bone collar forms chondrocytes in the cartilage shaft begin to _________, signaling the surrounding matrix to caclify

die cavities

step 2: the impermeableness of calcified chondrocytes causes the chondrocytes to _____ which cause the hyaline shaft to form _____

uncalcified elongation

step 2: cartilage remains healthy in _____ portions of the hyaline model resulting in the continued _____ of the model

periosteal bud invades and spongy bone forms

step 3 of endochondral ossification

artery, vein, lymphatic vessels, osteoblasts/osteoclasts, nerve fibers, red marrow elements

contents of the periosteal bud

osteoclasts osteoblasts osteoid

step 3: the entering _____ begin to erode much of the calcified cartilage matrix and the _______ secrete _____ around the remaining fragments of cartilage

cartilage trabeculae

step 3: the secretion of osteoid around the remaining calcified cartilage fragments creates this

the diaphysis elongates and medullary cavity forms

step 4 of endochondral ossification

osteoclasts medullary cavity

step 4: _____ break up the newly created spongy bone and form the _______ w/in the center of the shaft

epiphyses elongate ossification cartilage

step 4: throughout the fetal period the _____ remain as hyaline cartilage and thus continue to ______ the bone model and thus _____ chases _____ formation along the length of the shaft

the epiphyses ossify

step 5 of endchondral ossification

right before or after birth

period in which the ossification of the epiphyses occurs

secondary ossification center

step 5: a _________ forms in each epiphysis at the start of epiphyseal ossification

calcifies periosteal bud

step 5: the cartilage in the center of the epiphysis ______ and deteriorates, opening up cavities which allow a _____ to enter

spongy bone medullary cavity

step 5: mimics the ossification process which occured in the diaphysis with the exception that the _____ is retained and no ________ forms

articular cartilage

name for cartilage left on the epiphyseal surface after endochondral ossification

epiphyseal plate

name for cartilage left at the diaphysis/epiphyseal junction

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