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cell cycle checkpoint
Terms in this set (14)
regulatory points at which the cell examines internal/external cues to decide whether or not to move forward in division
most important checkpoints
-g1 checkpoint at the g1/s transition
-g2 checkpoint at the g2/m transition
-spindle checkpoint at the transition from metaphase to anaphase
-primary point at which the cell chooses to/not to divide
-once the cell passes this checkpoint and enters s phase, it becomes committed to division
-cell checks internal/external conditions if they're right for division; if not, it will stop cell from entering division
G1 CHECKPOINT: some factors the cell may assess:
is the cell receiving positive cues from its neighbors?
is the cell attached to a support?
is any of the dna damaged?
-to make sure that cell division goes down smoothly
-the cell is concerned with the condition of its dna
-if errors are detected, the cell will pause at the g2 checkpoint to allow for repairs
-if damage is irreparable, the cell may undergo apoptosis
g2 checkpoint: factors that are assessed:
was dna completely copied?
-chromosomes seperation is irreversible so the cell must make sure that the chromosomes are positioned properly and are ready to separate before leaving metaphase
SPINDLE CHECKPOINT: cell must confirm that:
all chromosomes are lined up along the metaphase plate
each chromosome is under tension from the spindle
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