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7 terms

Toxicology- Plants

Plant Toxicities
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Foxglove and other Digitalis: Toxic Principle
Toxic Principle
-Cardiac (digitalis) glycosides
- Sugar ester (aglycone) = toxic principle....not toxic until broken
-all parts of plant
Foxglove and other Digitalis: Mechanism of Action
-interfere w/ NaK ATPase (to)
- IC ↑Na, Ca ↓K
-interfere w/normal electrical conductivity in myocardium (to) AV block
Foxglove and other Digitalis: Toxicity
-high
- 2-3leaves lethal in sm SA
- 5-8g lethal in adult pig
Foxglove and other Digitalis: Conditions of Poisoning/Species at Risk
-all species
-drying
-increases palatability
-no change in toxicity
Foxglove and other Digitalis: Clinical Signs
Clinical Signs
-acute 5-24hrs
-nonspecific GI signs early: severe bloody diarrhea, colic
-CV signs: arrhythmias (AV block) asystole
-weakness, depression convulsions, coma
-COD: cardiac failure
Foxglove and other Digitalis: Diagnosis
-ID plant: stomach contents
-Pathology:
- ECG: conduction anomalies
- Nonspecific PM
Foxglove and other Digitalis:Treatment
Treatment
-GI decontamination
-AC, cathartics (don't give if diarrhea present)
-Digibind: antidigitalis toxin