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Hydralazine ~ Apresoline

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Terms in this set (10)
Body as a Whole: Hypersensitivity (rash, urticaria, pruritus, fever, chills, arthralgia, eosinophilia, cholangitis, hepatitis, obstructive jaundice).
CNS: Headache, dizziness, tremors.
CV: Palpitation, angina, tachycardia, flushing, paradoxical pressor response. Overdose: arrhythmia, shock. Special Senses: Lacrimation, conjunctivitis.
GI: Anorexia, nausea, vomiting, diarrhea, constipation, abdominal pain, paralytic ileus. Urogenital: Difficulty in urination, glomerulonephritis.
Hematologic: Decreased hematocrit and hemoglobin, anemia, agranulocytosis (rare).
Other: Nasal congestion, muscle cramps, SLE-like syndrome, fixed drug eruption, edema.
Lab tests: Determine antinuclear antibody titer before initiation of therapy and periodically during prolonged therapy. Make baseline and periodic determinations of BUN, creatinine clearance, uric acid, serum potassium, blood glucose, and ECG. Monitor for S&S of SLE, especially with prolonged therapy. Monitor BP and HR closely. Check every 5 min until it is stabilized at desired level, then every 15 min thereafter throughout hypertensive crisis. Monitor I&O when drug is given parenterally and in those with renal dysfunction.
Monitor weight, check for edema, and report weight gain to physician. Note: Some patients experience headache and palpitations within 2-4 h after first PO dose; symptoms usually subside spontaneously. Make position changes slowly and avoid standing still, hot baths/showers, strenuous exercise, and excessive alcohol intake. Do not drive or engage in other potentially hazardous activities until response to drug is known. Do not breast feed while taking this drug without consulting physician.