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22 - Endocrine Disorders

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I. Overview of Endocrine Disorders:
NEGATIVE FEEDBACK LOOPS
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Terms in this set (16)
STIMULATION TESTS - evaluate Hypofunctioning disorders

Example: ACTH stimulation test is used in the workup of Hypocortisolism

CAUSES OF HYPOFUNCTION:
1) Autoimmune Destruction:
- Addison's Dx
- Hashimoto's Thyroiditis
** Most common cause of Endocrine gland hypofunction is Autoimmune Dx


2) Infarction:
- Sheehan's Postpartum Necrosis
- Waterhouse-Friderichsen Syndrome

3) Decreased H'mone Stimulation:
- decreased TSH in Hypopituitarism

4) Enzyme deficiency, infection, neoplasia, congenital disorder
SUPPRESSION TESTS - evaluate HYPERfunctioning disorders

Example: Dexamethasone Suppression Test evaluates Hypercortisolism

Most hyperfunctioning disorders can NOT be suppressed
** Exceptions are Prolactinoma & Pituitary Cushing syndrome

CAUSES OF HYPERFUNCTION:
1) Adenoma
2) Acute Inflammation
3) Hyperplasia
4) Cancer