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used in the treatment of DM, can be rapid, intermediate or slow acting, has an anabolic effect on the body, and has a very narrow safety margin
Drug Interactions with Insulin
Diuretics, Hormones, Sympathomimetics, alpha 2 agonists, thyroid agents, phenytoin, phenothiazines
Stimulate basal insulin secretion by closing K+ Channels in the beta cell membrane and depolarizing the cell
Activates adenyly cyclase increasing cAMP which activates cAMP dependent protein kinase and substrate phosphorylation
Stimulates the heart,, hepatic glycogenolysis,gluconeogensis and lipolysis, relaxes smooth muscles,
non diuretic soluble in water; inhibits insulin release from B cells and stimulates release of catecholamines
act Intracellularlly; Bind to GRE in DNA, alter gene expression and protein synthesis
#1 use of Glucocorticoids
Antiinflammatory by inhibiting the immune system and maintaining micro circulation and reduce capillary membrane permeability, inhibits phospholipase A2, and COX2
Shortest acting glucocorticoids with the lowest level of mineralocorticoid activity, INCREASES APT
Inhibits monoamine oxidase B enzyme inhibiting activation of dopamine; treats PDH in dogs
GnRH clinical uses
Increases libido in dogs and cats, Diagnoses LH and testosterone def,, Same uses as LH
Androgens and Anabolic steroids
Are Under Schedule III under controlled substances act (CSA), treatment of androgen def (alopecia) in the castrated dog
Mismatching, Incontinence, dermatitis and vaginitis in spayed small animals, estrus induction, Antagonists to androgens in prostate hypertrophy and tumors and analadenoma
Norgestomet implants (maint dose) AND Norgestomet-estradiol-valerate, Syncro Mate B
Progestins approved lactating and beef cattle
Hydroxyprogesterone caproate, Medroxyprogesterone acetate
Behavioral and Urination problems in male cats
tx of psuedopreg in the *****
NONE, Water deprivation/diuretics, Androgens/estrogens, Dopamine agonist, NO OHE
Treatment of BPH in dogs
Castrations, Megaestrol acetate. FINNASTERIDE, GnRH ant, and Lg doses of GnRH agonist
Chemical Castration in dogs (Injected into the testicles)
Zinc/Calcium gluconate neutralized with arginine
Causes of Hypercalcemia
Malignant tumors, Hypoadrenocorticism, Chronic Renal failure, Primary hyperparathyroidism, Vit D intox
Treatment of Myxyedema Coma in dogs
L-thyroxine sodium (inj), Warming of the animal, Artificial respiration
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