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Drugs work by doing one more of the following to neurotransmitters:
1. Increasing the synthesis
2. Causing vesicles to leak
3. Increasing release
4. Decreasing reuptake
5. Blocking the breakdown into inactive chemical
6. Directly stimulating or block postsynaptic receptors
A drug has an _____ for a particular type of receptor if it binds to that receptor
- Can vary from strong to weak
Almost all abused drugs stimulate dopamine release in the _____ _____
- small subcortical area rich in dopamine receptors
- an area responsible for feelings of pleasure
Stimulate dopamine synapses by increasing the release of dopamine from the presynaptic terminal
Blocks the reuptake of dopamine but in a more gradual and more controlled rate (often prescribed for people with ADD)
- Increases the release of dopamine at low doses that account for its stimulant properties
- Increases the release of serotonin at higher doses accounting for its hallucinogenic properties
- May contribute to higher incidences of anxiety and depression as well as memory loss and other cognitive deficits
Found in the central nervous system, the nerve-muscle junction of skeletal muscles and in the nucleus accumbens. They are also abundant in the nucleus accumbens and facilitate dopamine release
- Drugs that are derived from the opium poppy
- Decrease sensitivity to pain and increase relaxation
- Ex: morphine, heroin, methadone
- The brain produces peptides called _____
- Inhibiting GABA indirectly releases dopamine
- Attach to the same receptors to which opiates attach
- Active ingredient in marijuana
- Attaches to cannabin receptors throughout the brain but especially in the cerebral cortex, cerebellum, basal ganglia, and hippocampus
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