CYCLO-OXYGENASE TYPE 2 ENZYME
_________________ is the enzyme responsible for producing prostaglandins which cause pain at sites of surgery, infection and inflammation.
Cyclo-oxygenase type 2 enzyme is the enzyme responsible for producing _______________ which cause pain at sites of surgery, infection and inflammation.
PAIN AT SITES OF SURGERY, INFECTION AND INFLAMMATION
Cyclo-oxygenase type 2 enzyme is the enzyme responsible for producing prostaglandins which cause ____________________.
When cyclo-oxygenase type two enzymes are inhibited, less __________ are produced and there is less pain.
FALSE! These drugs were developed because they caused LESS incidence of gastric ulcers compared to NSAIDs (ibuprofen, naproxen)...so good for patients with arthritis taking the drug for a long time and not suffer from ulcers....its also used to diminish dental pain
T or F? COX-2 inhibitors are not used for long periods of time because they have a higher incidence of causing GI ulcers.
COX-1 = produces prostaglandins in the GI tract that act as a protective substance against the formation of ulcers
COX-2 = produces prostaglandins which cause pain at sites of surgery, infection and inflammation
What is the difference between COX-1 and COX-2 enzymes?
NSAIDs (ibuprofen and aspirin) inhibit COX-1 enzymes thus diminishing the formation of the protective GI prostaglandins
What happens when COX-1 enzymes are inhibited?
LESS PROSTAGLANDINS ARE PRODUCED AND THERE IS LESS PAIN
What happens when COX-2 enzymes are inhibited?
BOTH COX-1 AND COX-2 soooo.....they are effective in pain reduction but also have the capability to produce ulcers, where COX-2 inhibitors will inhibit pain with a much lower chance of causing ulcers.
What enzymes do traditional NSAIDs inhibit?
Stomatitis, abnormal taste, xerostomia (normal salivary flow resumes upon discontinuation), and tooth disorder.
What are the effects on dental treatment of Celecoxib (celebrex)?
Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase-2 (COX-2), which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties. Celecoxib does not inhibit cyclooxygenase-1 (COX-1) at therapeutic concentrations.
Describe the mechanism of action of celecoxib (celebrex).
TRUE! Have Antipyretic, analgesic and anti-inflammatory properties
T or F? COX-2 inhibitors reduce inflammation.