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22 terms

Developmental Bio Exam #3

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Bicoid
anterior
Binds and inhibits caudal
Bicoid deficient mutant: Double tail
Bicoid "rescue" expts: wherever inserted gives rise to "head" region
nanos
posterior
Binds and inhibits hunchback
nanos deficient mutant: no abdomen
anchored by staufen and oskar
Torso
both anterior and posterior
Torso is a RTK.... represses groucho
tailless and huckbein mRNA in association with torso
torso deficient mutant: no telson and acron
torso-like
ligand
activates torso which represses Groucho
Groucho
middle
inhibited by torso
represses tailless and hucklebein
caudal
posterior
inhibited by bicoid (binds to the 3' UTR of caudal)
hunchback
ubiqiotous mRNA
deadenylation in posterior (so only expressed in anterior)
Gap genes
muntants missing large regions
pair rule genes
mutants missing every other segment
segment polarity genes
missing half of each segment
mutual rerpression
both inhibit eachother in synctium blastoderm
establishes polarity which gives rise to segments because of the morphogen gradients made
unilateral repression
hunchback does not directly inhibit krupel but ultimatley does
major primary pair rule genes
primary eve, rnt, paired
major secondary pair rule genes
add, ft3, sloppy-paired
what controls fine tuning of each segments?
modularity of enhancer regions of each gene
comboniations of enahncers determines which stripe its in
fushi tarazu mutant
mutations at borders of segments, these parts are called para segments
parasegments
posterior of each parasegment has no expression
regulation at each parasegment regulates where fuhi tarazu is found
what pathway are Wg and En in?
Wg-> Wnt
En-> Transcription factor
what type of regulation occurs between adjacent parasegment border cells with engrailed and wingless?
recipricol regulation
what establishes the parasegement?
wg and en
Hox genes
homeotic genes that give rise to structures in the order of the genes on the chromosome (5' to 3') as anterior-posterior
dont know why
can express legs as antennae
Homeotic genes
Function: activate and repress the "realisator" genes which form tissue and organ primordia
repressed by polycomb
activated by trithorax