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12 terms

humoral immunity

what type of infection is neutralization best for?
what are the best neutralizing antibodies?
IgA and IgG
What three antibodies are capable of neutralization?
IgA, IgG and IgM.

A and M can cross link and aggregate
what is digeorge syndrome? what are these children particularly susceptible to?
children born without a thymus, are fcked if they come into contact with an intracellular pathogen.
What are two cytokines secreted by CTLs?
IFN-gamma (activates macrophages to be extra pissed and have more oxidative burst to kill pathogens they have ingested)

TNF-Beta (enhances phagocytic activity of macrophages.)
What can be used to treat people with chronic granulomatous disease?
IFN-gamma. These patients cannot kill ingested pathogens, so if you give them IFN-gamma, they can do it!
General functions of cytokines secreted by CTLs
to activate macrophages.
IFN-gamma makes them better at bursting to kill intracellular pathogens
TNF-beta makes them more phagocytic.
What are the 4 cytokines secreted by Th1 cells?
What cytokines, when secreted by APCs, cause Th0s to differentiate into Th1s?
IFN-gamma and IL-12
What is the function of IL-2? Who makes it?
Th1s make IL-2, and activated T cells (here it promotes differentiation and proliferation). It also stimulates prolif of NK cells.
What cytokine, made by APCs and Th1s, inhibits Th2 differentiation?
What isotypes do Th1 cells stimulate B cells to switch to?
IgG1 and IgG3 - IFN-Gamma
IgA - TNF-Beta