What three antibodies are capable of neutralization?
IgA, IgG and IgM.
A and M can cross link and aggregate
what is digeorge syndrome? what are these children particularly susceptible to?
children born without a thymus, are fcked if they come into contact with an intracellular pathogen.
What are two cytokines secreted by CTLs?
IFN-gamma (activates macrophages to be extra pissed and have more oxidative burst to kill pathogens they have ingested)
TNF-Beta (enhances phagocytic activity of macrophages.)
What can be used to treat people with chronic granulomatous disease?
IFN-gamma. These patients cannot kill ingested pathogens, so if you give them IFN-gamma, they can do it!
General functions of cytokines secreted by CTLs
to activate macrophages.
IFN-gamma makes them better at bursting to kill intracellular pathogens
TNF-beta makes them more phagocytic.
What is the function of IL-2? Who makes it?
Th1s make IL-2, and activated T cells (here it promotes differentiation and proliferation). It also stimulates prolif of NK cells.