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Protein Metab

Terms in this set (20)

What are proteins in the PEST sequence?
Name them?
-proteins with short 1/2 lives
- Proline, Glutamate, Serine and Threonine
Proteins with 1/2 lives over 100 hours?
-Aldolase
-Lactase dehydrongenase
-Cytochromes
Where are Pentapeptide KFERQ selectively lost or otherwise kept in response to fasting?
Lost- Liver and Kidney
Kept- Brain and Testis
Reaction with Ubiquitin is retarded by amino terminal residues?
-Methionyl
-Seryl
Reaction with Ubiquitin is accelerated by amino terminal residues?
- Aspartyl
- Argynyl
Pancreatic proteases include...
-Trypsin
-Chymotrypsin
-Elastase
-Carboxypeptidase
What are endopeptidases?
They are? Which is most specific?
- cleave peptide bonds at various points within protein chain
-Trypsin, pepsin, chymotrpsin and elastase
-Trypsin- cleaves lysine or arginine
Elastase cleaves elastin, but also what other small side chains?
-alanine
-glycine
-serine
What are exopeptidases?
Name two?
- Cleave one amino acid at a timefrom the end chain.
-Carboxypeptidase and aminopeptidase
3 ways in which amino acids are absorbed from the intestinal lumen?
-through secondary active Na+ dependent transport
-through facilitated diffusion
-through transport linked to the gamma-glutamyl cycle.
In Gamma-glutamyl Cycle how many atp's are used?
3
The extracellular amino acid reacts with.....
Glutathione
What enzyme can accept both NAD+ and NADP+ ?
Glutamate dehydrogenase
What are the similarities and differences in non-oxidative deamination of the enzymes Amino acid dehydrase and Amino acid desulfhydrase?
both require pyroxidal PO4 as cofactor, while

dehydrase acts on hydroxy amino acids- serine, threonine and tyrosine
Desulfhydrase- acts on sulfur containing cysteine, homocysteine
Which aa can't undergo transamination reactions?
Lysine and threonine
Carrier or coenzyme during transamination?
PLP- pyridoxal-5-phosphate
Aminotransferases mostly except??
a-ketoglutarate (lesser extent oxaloacetate)
CPS 1
uses ammonia as its nitrogen donor, very dependent on N-AGA
CPS 2
uses glutamine, cytosolic in location, no n aga
Which process releases urea and regenerates ornithine?
Clevage of arginine by arginase
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