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places drugs excreted from
glomerlular filtration affected by:
1. kidney health/blood perfusion
2.chem/phys properties (only small mols filtered, protein bound drug is not filtered)
3. water soluble drugs can be reabsorbed in tubules
4. pH of urine
active secretion (affects kidney filtration)
proximal or distal tubules
penicillin concentrates in urine, good for UTI
bile stored in gallbladder, drugs actively secreted by livers cells into bile, through intestinal tract
-drug may get reabsorbed into body if its still lipophilic (enterohepatic circulation)
drugs go from blood to milk, may get ion trapped (normal pH of milk is 6-7, mastitis milk is 7-8)
half life of drug
amt of time it takes for half the drug to leave body
-antibiotics= 2-3 hr halflife
-barbituates= 30-70 hours
HOW DRUGS EXERT EFFECTS
-drug binds to target cells at receptor sites on cell
-receptor sites are different (unique for drug)
-drug + correct receptor= desired response
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