Ritalin, Metadate, Methylin, Concerta
mixed amphetamine salts
Immediate release products
Ritalin, Adderall, Dexosyn
IR products DOA
3-4 hours, maybe up to 12 hours for Adderall, dosed BID-TID
R-isomer of methylphenidate, smoother effect (less ups and downs, rebounds and insomnia), allows for higher dose, start at half the methylphenidate dose
as a group, ER products have what characteristics?
once daily dosing, increased compliance, decreased appetite
Ritalin SR info
delayed release, no effect seen for 1st 2 hours, DOA is 4 hours
Dexedrine Spansule info
no evidence of extended action
Metadate ER info
linear release, DOA is 6 hours
OROS delievery system (shell is impregnated with drug to get quick release (22%), then GI fluid enters capsule and makes it swell, small amounts of drug are pushed out the hole in the cap for timed release beginning 4 hours after ingestion (78%))
Metadate CD info
30%/70% beaded system, mimics two doses of immediate release product
Ritalin LA and Adderall XR infor
50/50 beaded formulation, mimics two doses of immediate release products
D-amphetamine prodrug, lysine moiety is cleaved in GI tract, less abuse potential
transdermal methylphenidate, worn on hip for 9 hours
adverse effects of stimulants
decreased appetite, decreased growth, insomnia, rebound, SUDDEN CARDIAC DEATH
selective NE reuptake inhibitor, not a stimulant, once daily dosing, effects may not be seen for 2-4 weeks, liver toxicity and suicide
alpha-2 agonist, once daily dosing, not controlled, Tenex is not the same on a mg-mg basis
CNS arousal agent, indicated for narcolepsy, euphoric effect but low abuse potential
second line agents
bupropion, venlafaxine, clonidine
Please allow access to your computer’s microphone to use Voice Recording.
We can’t access your microphone!
Click the icon above to update your browser permissions above and try again
Reload the page to try again!
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Your microphone is muted
For help fixing this issue, see this FAQ.