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15 terms

Cholinergic Therapeutic Uses

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bethanechol
GI bladder stimulant, xerostomia (dry mouth)
methacholine (Provocholine)
asthma diagnosis
direct cholinergic choline esters and congeners
ACh, methacholine, carbachol, bethanechol
direct cholinergic alkaloids
muscarine, pilocarpine
indirect reversible cholinesterase inhibitors
physostigmine (eserine), neostigmine, pyridostigmine
physostigmine (eserine)
reversible AChase inhibitor, no quat. structure, penetrates into CNS
neostigmine
Dx: myasthenia gravis
pyridostigmine
protection against organophosphate gases, Tx: myasthenia gravis
CNS selective cholinesterase inhibitors
donepezil, tacrine (Cognex), rivastigmine, galantamine
Indirect irrever. AChase inhibitors
organophosphates, phosphate esters, echothiophate
pesticides
parathion, malathion
war gases
tabun, soman, sarin
irrever. AChase inhibitor antidote
atropine + pralidoxime (2-PAM)
slowly reversible AChase inhibitors
sevin (Carbaryl)
slowly rev. Achase inhibitor antidote
atropine + support