GI bladder stimulant, xerostomia (dry mouth)
direct cholinergic choline esters and congeners
ACh, methacholine, carbachol, bethanechol
direct cholinergic alkaloids
indirect reversible cholinesterase inhibitors
physostigmine (eserine), neostigmine, pyridostigmine
reversible AChase inhibitor, no quat. structure, penetrates into CNS
Dx: myasthenia gravis
protection against organophosphate gases, Tx: myasthenia gravis
CNS selective cholinesterase inhibitors
donepezil, tacrine (Cognex), rivastigmine, galantamine
Indirect irrever. AChase inhibitors
organophosphates, phosphate esters, echothiophate
tabun, soman, sarin
irrever. AChase inhibitor antidote
atropine + pralidoxime (2-PAM)
slowly reversible AChase inhibitors
slowly rev. Achase inhibitor antidote
atropine + support
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