If I test for the health of the one million Renal Corpuscles that are present in one
healthy Kidney, what process will I be testing?
Filtration (GFR - Glomerular Filtration
Rate ‐ dependents upon):
a. Effective Renal blood Flow.
b. Healthy Glomerulus
c. Healthy Bowman's capsule
What is the filtered blood at the beginning of the Nephron tubule called?
"Filtrate". The filtrate travels through
the hollow tube that is called the Nephron and eventually becomes Urine
What is the major location of the action of ADH (antidiuretic hormone)?
collecting duct via aquaporins (special receptors)
What is the role of the Renal Pelvis?
Is a collection of tubule that simply collect Urine
and coalesce together to form the Ureter
What is the major difference in the shape of size of the Loop of Henle in Cortical &
Juxtamedullary nephrons have a long loop of Henle (Cortical nephrons have a short loop of Henle)
What percentage of the Filtrate will become Urine?
1000 ml of filtrate is formed,
how much will eventually becomes urine? 10 ml. only 1% of the filtrate becomes Urine.
What happens to the 99% of the filtrate within the Nephron that does not become
It is reabsorbed by the Nephron into the Interstitial space and taken up by the capillaries that line alongside the Nephron (Peritubular network of capillaries)
How is Angiotensin 2 produced?
By the action of ACE (Angiotensin converting
enzyme) on Angiotensin 1
What hormone is responsible for the reabsorption of water from the Nephron?
ADH (antidiuretic hormone)
In SIADH what will happen to the urinary output?
Less urinary output, more concentrated urine. Urine Specific gravity will be high
In Diabetes Insipidus what will happen to the urinary output?
More urinary output,less concentrated urine. Urine Specific gravity will be low
Can any substance be found in the Urine that is not filtered by the Nephron?
Yes,by the process of Secretion
What are the three zones observed in the cut section of the Kidney
a. Cortex (outer zone)
b. Medulla (middle zone)
c. Pelvis (inner most zone)
What are the three major processes that are involved in the creation of Urine by the