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Biochem- Nitrogen Metabolism IV
What are the two amino acids that start catecholamine synthesis
What enzyme acts on tyrosine? coenzyme? product?
What enzyme acts on DOPA? coenzyme? product?
What enzyme acts on dopamine? coenzyme? product?
What enzyme acts on NE? coenzyme? product?
Phenylethanolamine N methyl transferase
What causes parkinsons disease
loss of Dopamine producing cells
What is the treatment of Parkinsons disease?
What enzymes are involved in Catecholamine degradation
MAO and COMT
What is the product of MAO and COMT
What are high urinary VMAs and Catecholamines indicative of
What is pheochormocytoma
overproduction of catecholamines by a adrenal medulla tumor
What amino acid starts serotonin synthesis?
What enzyme acts on tryptophan? coenzyme? product?
What enzyme acts on Hydroxytryptophan? coenzyme? product?
What enzyme degrades serotonin? product
What is carcinoid syndrome
Tumor of serotonin producing cells in the GI
What molecule is increased in the urine of a patient with carcinoid syndrome
What is melatonin derived from?
What is serotonin derived from
What 3 reaction require BH4
Phenylalanin Hydroxylase (Phe to Tyr)
Tyrosine Hydroxylase (Tyr to DOPA)
Tryptophan Hydroxylase (Trp to 5 Hydroxytryptophan)
What would BH4 deficiency cause?
decreased NT synthesis (catecholamins serotonin)
What type of NT is GABA
What is GABA formed from?
What enzyme forms GABA and what coenzyme
What enzyme produces histamine? cofactor? Input?
AA Decarboxylase makes histidine from histamine with PLP
What is the function of histamine
What is the action of antihistamines
reduce the ability of histamine to function as a signal
What is creatine synthesized from
What is the relationship of Creatine with ATP when the muscle is resting
What is the relationship of Creatine with ATP when the muscle is contracting
Donates P groups to ADP
What is creatine made into?
What is the end product of creatine metabolism
What molecule is used to track muscle mass and muscle atrophy through urine
creatinine and CK
What is NO synthesized from? Enzyme and coenzyme
What does NO do?
What is deficient in albinism
What three AA's make glutathione
What is the use of glutathione
Detox of H2O2
What do 2 GSH form?
What enzyme changes GSSG to GSH