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40 terms

Biochem- Nitrogen Metabolism IV

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What are the two amino acids that start catecholamine synthesis
Tyrosine
Phenylalanine
What enzyme acts on tyrosine? coenzyme? product?
Tyrosine Hydroxylase
BH4
FOrms DOPA
What enzyme acts on DOPA? coenzyme? product?
DOPA Decarboxylase
PLP
Dopamin
What enzyme acts on dopamine? coenzyme? product?
Dopamine B-Hydroxylase
Vit C
NE
What enzyme acts on NE? coenzyme? product?
Phenylethanolamine N methyl transferase
SAM
Epinephrine
What causes parkinsons disease
loss of Dopamine producing cells
What is the treatment of Parkinsons disease?
L-DOPA
What enzymes are involved in Catecholamine degradation
MAO and COMT
What is the product of MAO and COMT
VMA
What are high urinary VMAs and Catecholamines indicative of
pheochromocytoma
What is pheochormocytoma
overproduction of catecholamines by a adrenal medulla tumor
What amino acid starts serotonin synthesis?
Tryptophan
What enzyme acts on tryptophan? coenzyme? product?
Tryptohpan hydroxylase
BH4
5-Hydroxytryptophan
What enzyme acts on Hydroxytryptophan? coenzyme? product?
AA Decarboxylase
PLP
Serotonin
What enzyme degrades serotonin? product
MAO
5-HIAA
What is carcinoid syndrome
Tumor of serotonin producing cells in the GI
What molecule is increased in the urine of a patient with carcinoid syndrome
5-HIAA
What is melatonin derived from?
Serotnin
What is serotonin derived from
tryptophan
What 3 reaction require BH4
Phenylalanin Hydroxylase (Phe to Tyr)
Tyrosine Hydroxylase (Tyr to DOPA)
Tryptophan Hydroxylase (Trp to 5 Hydroxytryptophan)
What would BH4 deficiency cause?
hyperphenylalaninemia
decreased NT synthesis (catecholamins serotonin)
What type of NT is GABA
inhibitory
What is GABA formed from?
glutamic acid
What enzyme forms GABA and what coenzyme
Glutamate decarboxylase
PLP
What enzyme produces histamine? cofactor? Input?
AA Decarboxylase makes histidine from histamine with PLP
What is the function of histamine
vasodilator
What is the action of antihistamines
reduce the ability of histamine to function as a signal
What is creatine synthesized from
SAM
ARginine
Glycine
What is the relationship of Creatine with ATP when the muscle is resting
Accepts P
What is the relationship of Creatine with ATP when the muscle is contracting
Donates P groups to ADP
What is creatine made into?
creatinine
What is the end product of creatine metabolism
creatinine
What molecule is used to track muscle mass and muscle atrophy through urine
creatinine and CK
What is NO synthesized from? Enzyme and coenzyme
Arginin
NO Synthase
Citrulline
What does NO do?
local vasodilation
What is deficient in albinism
melanin
tyrosinase enzyme
What three AA's make glutathione
Glutamate
Cysteine
Glycine
What is the use of glutathione
Detox of H2O2
What do 2 GSH form?
GSSG
What enzyme changes GSSG to GSH
Glutathione reductase