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Normal glomerulus, light microscopy in trichrome stain. Blue - glomerular truft and blue BM of cap wall . ure1
Normal glomerulus - EM; L = lumen, e - endothelial cell body; M=mesengial cell; F= foot processes; p = podocyte; U = urinary space
normal glomeruli - Glomerular filter EM, Capillary Lumen, Urinary space, Fenestration; Endothelial cell; BM of laminar rara and lamina densa; slite diaphragm, Foot processes
Minimal change disease - Foot process fusion in EM. Loss of GBM negative charge causes selective loss of albumins, but not globulins
Focal segmental glomerulosclerosis - trichome stain - mesangial matrix and cell increased
- high recurrence rate (50% even after transplant)
- can recur immediately after kidney transplantation (indicates circulating factor responsible for disease)
Poststreptococcal glomerulonephritis - granular appearance d/t IgG, IgM and C3 depositions in GBM and mesangium
Membranoproliferative glomerulonephritis - lobular pattern and hypercellular, cannot see open capillary loops
increased lobulation of glomerulus
Membranoproliferative glomerulonephritis - PAS shows BM duplication (tram track) and mesangial hypercellularity
Membranoproliferative glomerulonephritis - granular IgG deposition in mesangium and subendothelium
increased lobulation of glomerulus
Membranoproliferative glomerulonephritis type `- subendothelial layer - cells try to cover it to make tram tracks
BM duplication and subendothelial electron-dense deposits (blue arrows)
Membranoproliferative glomerulonephritis - type II - very dense, large crescent shape of deposit
Band-like subendothelial deposition of C3
Cryoglobulinemia (cryoglobulin because Ab to Ab to Ag) - seen in Membranoproliferative glomerulonephritis
Rapidly Progressive (crescent) GN - hypercellular glomerulus, crescents, fibrin deposition and collapse of glom tuft
Severe injury causes glomerular tuft fragmentation and and a break in capsule (double arrow)
Rapidly Progressive (crescent) - Proliferation of parietal epithelial cells lining Bowman's Capsule and mononuclear cell infiltrate. There are prominent fibrin strands btwn the cell layers in the crescents.
Amyloidosis - expansion of mesangium by amyloid fibrils that are 8-10nm in diameter. Individual fibrils within each plane interlace to form groups of fibers in parallel.
Amyloidosis - Amorphous acellular meterial expands mesangial areas and obstructs glomerular capillaries.
Diabetic nephropathy - Pseudo-linear peripheral IgG and Albumin deposits and nodular mesangial IgM + C3 deposits
Diabetic nephropathy - IgG and IgM and albumin sticking in blood vessels
Deposits of amorphous material in vessels (arteriosclerosis)
Diabetic nephropathy - Kimmselstiel-Wilson nodules (nodular expansion of PAS positive, mesangial matrix)
1. Capillary Basement Membrane Thickening
2. Diffuse Mesangial Sclerosis (PAS+ staining)
3. Nodular Glomerulosclerosis
4. Hyalinizing Arteriosclerosis (worst in the hilar vessels)
Lupus nephropathy - granular mesangial IgG, IgM, and complement deposits
corner looks like its looped for lupus
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