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Risk factors?

1. Smoking
2. Chemical exposure: dye, cytoxan, napthylamine
3. Chronic irritation: bladder stones, chronic indwelling catheter

What's the primary lymphatic drainage?

Hypogastric, obturator, iliac (int and ex), perivesical, sacral, presacral

What's the secondary lymphatic drainage?

Common iliac

What histologic types are there?

TCC 90% cases
SCC 5%
Adenoca uncommon

Where would you see adenoca of bladder?

Dome of bladder, urachal remnant

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