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Factors that influence tissue repair/Selected clinical examples of tissue repair and fibrosis
Terms in this set (17)
What is clinically the most important cause for delay in healing?
How does nutrition impair wound healing?
Vitamin C deficiency inhibits collagen synthesis
How do glucocorticoids affect wound healing?
- They have anti-inflammatory effects
- Sometimes weaken the scar because it inhibits TGF-B production (which stimulates production of collagen, fibronectin and proteoglycans)
What may happen because of mechanical variables?
Do poor perfusion and foreign bodies impair wound healing?
Yes, poor perfusion and foreign bodies impair wound healing.
Why is the type and extent of tissue injury important to consider in wound healing?
Only labile and stable tissues can have complete restoration.
What is a keloid?
The accumulation of exuberant amounts of collagen which gives rise to prominent, raised scars.
Amongs which ethnicity are keloids more common?
African-Americans with a heritable predisposition
What is "proud flesh"?
Healing wounds which generate excessive granulation tissue that protrudes above the level of the surrounding skin and hinders re-epithelialization.
How does the cutaneous incision look when healing is done by first intention?
The incision causes only focal disruption of epithelial basement membrane continuity and death of relatively few epithelial and connective tissue cells. As a result, epithelial regeneration is the principal mechanism of repair.
What happens after 24 hours, 3 days and 5 days of healing by first intention?
24 hours = neutrophils migrate towards fibrin clot; basal cells at the cut edge of the epidermis begin to show increased mitotic activity
3 days = neutrophils are replaced by macrophages
5 days = neovascularization reaches its peak as granulation tissue fills the incisional space
What is characteristic of healing by second intention?
The inflammatory reaction is more intense, and there is development of abundant granulation tissue with accumulation of ECM and formation of a large scar, followed by wound contraction mediated by the action of myofibroblasts.
The scar formed by secondary healing is rich in what proteins?
Fibrin and fibronectin
What are myofibroblasts?
Modified fibroblasts exhibiting the features of contractile smooth muscle cells.
How does the strength of a carefully sutured wound compare to that of normal skin?
What does "fibrosis" mean?
The term "fibrosis" is used to denote the excessive deposition of collagen and other ECM components in a tissue. "Scar" and "fibrosis" are used interchangeably, but fibrosis most often refers to the deposition of collagen in chronic diseases.
What induces fibrosis?
- Persistent injurious stimuli (infections, immunologic reactions)
- Other types of tissue injury
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